HATE METHOTREXATE...but it's kinda working?

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New Member

Date Joined May 2006
Total Posts : 1
   Posted 6/8/2010 4:37 PM (GMT -7)   
Hi everyone.  I have been on methotrexate for about 4 months.  From the first injection i've hated it.  I ran fevers, had the chills, neasea, extreme fatigue, and list goes on.  Had a colonoscopy a week ago and doc found that I had a stricture where I was reconnected after surgery in 2008.  It's almost completely closed.  He couldn't even get the scope through.  Last week I also went into manhattan to have a mr enterography gi series done at mt. sinai hospital which sucked.  Haven't gotten the results yet.  In the meantime i'm injecting twice a week of the methotrexate b/c i cannot handle the full dose in one shot.  I hate this drug, it makes me feel sick and I can't stand it.  I want to stop taking it but the doctor has says that despite the stricture it looks the meds are helping.  Only thing is my rectum is in active inflammation. I don't know what to do.  I want to stop taking the drug but it's my last resort.  I've been on everything else.  There is nothing else besides tysabri and I DO NOT want to be on that.  Anyone have a similiar situation with the methotrexate?  I could really use some advice.  Thank you.  :)

Elite Member

Date Joined Jan 2005
Total Posts : 24909
   Posted 6/8/2010 5:06 PM (GMT -7)   
Hi n welcome to the forums
sorry i take mtx in pill form n it helps me
i know others will be around to help you out
so sorry you are going thru this
tk care n again welcome
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New Member

Date Joined Jun 2010
Total Posts : 2
   Posted 6/8/2010 8:27 PM (GMT -7)   
I was on Methotrexate! It made me sick and the hair on arm fell off.  It worked for me for about 2 months and then stopped.  

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 6/9/2010 6:01 AM (GMT -7)   
I LOVED being on mtx and would give anything to be able to take it again.  It was the only thing that helped enough with the arthritis, but it raised my liver enzymes and I had to discontinue it.  I didn't have any other side effects from it.  I miss it.  =(

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

Regular Member

Date Joined Apr 2010
Total Posts : 76
   Posted 6/9/2010 6:25 AM (GMT -7)   
I take Mtx orally since January and don't know if its doing anything as I can't get off the steriods. In the first few weeks I did feel really tired, had chills and felt generally unwell the next day (come to think of it I still do, maybe I'v come to accept the side effects !) Hope you get some answers soon.
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