methotrexate and hair loss

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New Member

Date Joined Dec 2008
Total Posts : 12
   Posted 6/11/2010 8:26 PM (GMT -7)   
Hi out there--I have been on Methotrexate for about four months now and it is really helping with the joint pain, but over the past three weeks, my hair is really falling out. I am so bummed. I have been taking my folic acid religiously. Anyone have this problem and have suggestions for what I might do to stop the hair loss? I am not taking more pharmaceuticals for this, but would be interested in all suggestions.
Used to be normal...but now...I'm just frustrated and want my life back...Struggling to keep my head above water
37, Dxd with Crohn's, IBS, Fibromyalgia, Depression, Anxiety, Asthma
Just started Remicade, also taking Azathioprine (Imuran), Entocort on and off, Levbid, Cymbalta, Lexapro, Xanyx, Nexium, Singulair, pain meds as needed

Elite Member

Date Joined Jan 2005
Total Posts : 24909
   Posted 6/12/2010 4:52 AM (GMT -7)   
hi there
i hv no idea either i take both mtx n folic acid and hv lost so much hair
im sure ppl will post n give us insight
i believe its from mtx
tk care
         HV Crohns..pyoderma gangrenosum..anxiety..neuropathy...fibro
                      seizures ..totally deaf within last yr                                   
  meds...lyrica..valproic acid..pentasa..b 12 shots ..ativan..diazepam..dilatin  


Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 6/12/2010 6:32 AM (GMT -7)   
I heard that you can add Biotin into the mix and this will help slow the hair loss. I tried the Biotin, but it didn't agree with me, but...I am more sensitive to supplements than most. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 6/12/2010 8:31 PM (GMT -7)   
I've also been on mtx about 4 months. I lost a ton of hair over the past couple of years from all the medications (long-term steroid use) and the disease itself. Lately I feel like I've lost even more (not much left to lose!). I also take my folic acid every day as told. I just added biotin and B-12. (total = women's daily vitamin, 1200 mg calcium, 1,000-5,000IU D (depending on the day, I alternate),

I tried Nioxin (shampoo/scalp therapy) and after 6 months gave that up because I was losing more hair. I just started Rogaine, so I'll see in a few months if I can see any new growth. (just started the biotin, too, so I don't know if it's helping, but it can't hurt)

it's so hard to lose so much hair!! Good luck and keep us posted if you find the answer!
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09

Regular Member

Date Joined Jan 2010
Total Posts : 448
   Posted 6/13/2010 5:47 AM (GMT -7)   
when i STOPPED the MTX, I woke up with a pilloe of 1-2 inch hairs daily. Comb Full of it as well.. I did feel better on Mtx.. Fistula RE-opened as i continued prednisone and stopped MTX.

Was on it only for 6 weeks. STopped it Due to TPN. 2 together can't be done for septic, infection and liver issues.

to answer your questions.
I lost hair. But i Buzz cut it anyway. :)
Male, 22. Diagnosed with Crohn's officially since 2001.. Osteoporosis, Generalized Anxiety Disorder, Chronic Anemia.

Medications Used: Remicade, Humira, Cimzia, 6-mp, Pentasa, Flagyl, Prednisone, Zifaxan, Entocort,
TPN (Total Parenteral Nutrition), The whole nine.

Currently:, Entocort EC, Vitamin D, Fentanyl 12mcg / 72hrs, TPN, Cardizem
Currently On SSDI

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