I got horrible nausea on imuran, but that was a 2-3 weeks into it. Now my nausea, I believe, is completely unrelated to medications and just some random symptom that goes with my Crohn's. For me it happens when I'm hungry/empty stomach. It also happens other times when I can't point to a potential link for a cause.
My doctor gives me Phenergan and it works great. Some people seem to get sleepy on it, but I don't notice that I've taken one in any way. No loopiness, no sleepiness, just ending of the nausea.
Before the Rx, I used Pepto Bismol.
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09