Azathioprine and Allopurinol together?

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Regular Member

Date Joined Aug 2008
Total Posts : 351
   Posted 7/17/2010 9:24 AM (GMT -7)   
So I have been on methotrexate for the past 6 months and no response.  I've been on all the drugs.  Everything.  I went to see a dr. in manhattan to get a second oppinion on what to do with me now since i've had surgery also and the crohn's came back within 7 months.  So he decided to put me on Azathioprine and Allopurinol together.  I've been on 6mp before and it made my liver function abnormal and white blood count high?  I'm not sure.  So he said if I was to be put on these two drugs together it interferes with the azathioprine doing that to the body.  Idk.  I don't understand and I'm wondering if anyone here is on these two drugs together and if it's helping you at all.  I'm at the end of my rope here.  I have a pretty bad stricture at the reconnection site of my sugery and i have a hernia now at my belly button.  I can't win.  I need something that will work.  Dr. in Manhattan wanted to put me on tysabri but I read about all the people that have come down with that brain infection and have died within six months.  No thank you.  Not for me.  Please if anyone can shed some light on this I would greatly appreciate it.  Thank you.

New Member

Date Joined Aug 2010
Total Posts : 18
   Posted 8/23/2010 8:55 AM (GMT -7)   
Bella, sorry, sounds frustrating.

I just came off of a very long remission and got spoiled, as I almost forgot how gripping this disease can be. Upon looking at my lab work, the doc said that I wasn't metabolizing my azathioprine effectively. He put me on allopurinol to boost the performance of my azathioprine. I've cut my dose of azathioprine in half and am in the process of getting my levels in order. I'm only 3 weeks into this process.  Fingers crossed.

I'm dealing with a stubborn flare and am stuck on 40mg of prednisone and corticosteroid enemas right now. I'll let you know if I find some relief from it.

Diagnosed with U.C. (Proctosigmoiditis) June 2003
June 2003 - July 2004 - All corticosteriods and 5-ASAs
July 2004 - March 2010 - REMISSION! (Thank you Imuran)
March 2010 - present - stubborn flare :(

Regular Member

Date Joined Jun 2014
Total Posts : 469
   Posted 10/14/2014 8:17 AM (GMT -7)   
How have you gotten on with the combo?

Regular Member

Date Joined Jun 2014
Total Posts : 469
   Posted 10/16/2014 12:31 AM (GMT -7)   
Anyone? I started this combo yesterday and am a little anxious. Please let me know of any success stories!
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