Mesalamine meds like Pentasa and Lialda causes a small percentage of people to have an increase in intestinal problems - diarrhea for one. If this is what you mean by getting worse when you take them, you might want to consider this to be the problem. My mother has UC and when she took Colazal [a Mesalamine compound] the number of BMs doubled.
Keeping a record of what "gets worse" when you take the meds, and then discussing that with your GI might help him decide if the medication is the culprit.
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