How best to take prednisone

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Regular Member

Date Joined Feb 2005
Total Posts : 232
   Posted 8/9/2010 5:44 PM (GMT -7)   
I just started on prednisone for the first time in a few years. I'm on 60mg taken all in the morning right now. I'm taking all at once because I've had problems sleeping on pred before. This time I'm getting headaches that build during the day and by night it's pounding. Should I split the dose in two? Any supplements or ideas for getting rid of the headaches. Tylenol does nothing.

Veteran Member

Date Joined Feb 2010
Total Posts : 925
   Posted 8/9/2010 6:16 PM (GMT -7)   
Gosh, taking it all at once was hard on me.  I would (me personally) would split it up a bit trying to balance out the wired up feeling with enough time to wind down to sleep a bit.  I was taking it for something else last year and that JA doctor gave me 5 50mg pills(take 1 a day for 5 days).  I foolishly took a whole pill the first day before I realized 1) that there was not taper plan, and 2) that a solid 50mg all at once was going to make me feel like I was awake for 2 straight days.  I like taking it in the smaller doses throughout the day.  It helps keep some of my mental anguish, short fuse and other issues at bay, at least a little better.
Diagnosed (FINALLY) UC Sept 09/Diagnosis amended 5-3-10 to Crohn's
Taking Pentasa 500mg/8x/day
Entocort 3X/day
Bentyl as needed
1000 mg Vitamin C
Prilosec 1X/day

Veteran Member

Date Joined Oct 2009
Total Posts : 1070
   Posted 8/9/2010 6:58 PM (GMT -7)   
This is clearly a question for your doctor to answer. I always took mine in the morning because I would be awake most of the night otherwise.

Veteran Member

Date Joined Mar 2005
Total Posts : 1289
   Posted 8/9/2010 8:50 PM (GMT -7)   
when i was on 60 i did 30/30...i pretty much did it that way until i was down to 15 or so and then took it all in one dose in the am
36 year old male living in AZ.  Diagnosed with Crohns at age of 15.
Currently on 30 mg prednisone.  still taking Asacol.  Just had 3rd Remicade infusion 3 weeks ago
In the middle of a bad flare now for over a year...lost almost 30 lbs. -- gained most of it back now.

Veteran Member

Date Joined Jun 2010
Total Posts : 1548
   Posted 8/10/2010 4:19 AM (GMT -7)   
I have never taken more than 40 mg as one dose. If I am on 40 mg or less I take it all in the morning so I can sleep. If I am on 60 mg, my doctor would have me take 40 mg in the morning before 9 am and 20 mg before 6 pm. He said this would hit the 2 natural peaks people have. Then when I would start to taper I would taper the night dose first until I was down to 40 and back to just a morning dose.
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 20 mg Prednisone, 2g Sulfasalzine, Butyric Acid, Kefir/probiotics, Curcumin, Magnesium, D3, B complex vitamin, and multi-mineral. Previously on Remicade, stopped Humira after 9 months, wasn't working.

No surgeries so far.

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 8/10/2010 5:57 AM (GMT -7)   
What does your doc think?

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 8/10/2010 7:09 AM (GMT -7)   
Wow some docs use TOO high a dose of Pred in my opinion. I never take more than 30 mg at the highest, or else I feel miserable. I would call your doc though, those headaches are worrisome. Hugs!
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Apr 2009
Total Posts : 166
   Posted 8/10/2010 2:08 PM (GMT -7)   
I like cupcakespinkgal's strategy, but I would check with your doctor. I have only taken 50 and below, and I took 50 all at once in the morning. However, I was pretty much bed ridden at the time so it had little effect that I noticed until I got to 40. Then some energy and the 'roid rage kicked in!!

The headaches are awful. Tylenol doesn't do it for me either. Are you taking anything else with the prednisone? I find that the salofalk gives me the headaches, not so much the prednisone. Maybe it is a combination of meds. Again, I would check with your doctor.
45 years old. Diagnosed with moderate to severe Crohn's in April 2005. Hiatus hernia diagnosed in 2008. Had Crohn's under control until March last year when I had a major flare up and ended up in hospital. Diagnosis is now CD and IBS. Getting it under control again.
Currently taking: Salofalk 2000 mg, Calcium and Vitamin D, Matamucil, Yogurt for probiotics, Pregnancy Vitamins for iron etc., Salofalk suppositories as needed.
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