Flare while on Remicade?? What happens?

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Regular Member

Date Joined Sep 2009
Total Posts : 115
   Posted 8/22/2010 6:06 AM (GMT -7)   
My husband has been on Remicade for the past 9 months and has done wonderfully.  about 2 months ago, his GI doc increased his dose to 10mg/kg in hopes to increase the interval between infusions.  For the past 2 weeks, my husband has had increased D, lots of pain, and nausea.  I am wondering if anyone out there has experienced this or any type of flare while on Remicade.  If so, what happened?  I really don't want him to stop the Remicade because it has done wonders for his (and my) life.  Any input would be very very helpful!!!!
---Andrea, wife of Crohn's patient

Veteran Member

Date Joined Feb 2003
Total Posts : 1811
   Posted 8/22/2010 7:24 AM (GMT -7)   
Yes, you can flare while on remicade. I did several times over the 6 years I took it. My doc always boosted me with prednisone to try and quiet things down. There were 2 different times where I took 6mp in addition to the remicade. One time it helped, one time it didn't. I finally found what worked for me by changing my diet (Specific Carbohydrate Diet) and that calmed the flare. Remicade is a wonder drug (at least it was for me), but it doesn't keep things quiet 100% of the time. That doesn't mean he has to come off of it, he just might have to do some other things to help the flare. Good luck to you! I hope his flare quiets soon.

Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 8/22/2010 12:07 PM (GMT -7)   
My husband is on Remicade 5mgs every 8 weeks. Last year in October, he developed severe swelling of his knee and his neck and back were also inflamed and he was basically stiff as a board and in a lot of pain. But his bowel was completely normal. We saw his GI, who was astonished to see how much swelling he had, and immediately referred him to a Rheumatologist, who deemed his situation either Crohn's arthritis or reactive arthritis, and put him on steroids 40 mgs. In the meantime, he got tested for Lupus and RA, which thankfully were both negative, and since the steroids alone weren't doing it for him, they moved his remicade to every 6 weeks. And he finally got relief. Once this episode was under control, they moved his remicade infusions back to every 8 weeks.

So, yes, you can have inflammation even when you are on Remicade. If this happens, the docs will either add another med (steroid, imuran, mtx) to the mix and/or increase the frequency and/or the dosage of the remicade infusion.

Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
C-diff recurrence Sep 2009
Reactive Arthritis Nov 2009
Currently c-diff free
Osteopenia of spine (Mar 2010)
Canasa (1gm), Lialda (4.8 gms), Remicade (8 weeks)
Currently In Remission

artist guy
Veteran Member

Date Joined Jan 2010
Total Posts : 1373
   Posted 8/22/2010 4:35 PM (GMT -7)   
I'm on rem, and absolutely I still flare, but they don't last as long and they're somewhat controlled with pain med's, pred and i are like water and oil, we don't mix well. my dr's are great with me and let use vicodin instead of pred, they also understand that I've had cd for 40 years and many surgeries, so my body is permanetaly alltered, and med's only help just so much, I've had 9ft of small bowel removed from disease, so I really get along good with my doc's. they are totally with me on my ssdi app. I've been denied the first time but it is typicall, I've got binder and binder as my disability lawyer's and i have 2 case workers who call and update me. Just a darn shame we're sick, darn shame.

artist guy
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