antibiotic use in first year of life might increase chances of getting Crohn's

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Date Joined Apr 2006
Total Posts : 1885
   Posted 9/14/2010 9:21 PM (GMT -7)   
My daughter had amoxicillin prescribed for her when she was only four months old...

Antibiotic Prescriptions in the First Year of Life Increases the Risk of Pediatric Inflammatory Bowel Disease: A Population-Based Analysis (Abstract #95)

"By comparing cases of pediatric IBD and antibiotic use, researchers from the University of Manitoba have discovered that infants who are prescribed antibiotics in the first year of life may be three times more likely to develop lifelong IBD than children not exposed to antibiotics. Researchers believe that antibiotic use in infants can cause irrevocable impact to developing bowel flora, or bacteria, in the human bowel. Changes or irregularities in bowel flora are thought to be a potential cause of IBD. Bowel flora is established and remains relatively unchanged after one year of age. Taking antibiotics can temporarily change bowel flora, but after, use flora revert back...To confirm this study’s findings, more research with another population and larger sample sizes is necessary."

Souradet Y. Shaw, MD, will present these data on Sunday, May 2 at 10:30 a.m. CT in 295-296, Ernest N. Morial Convention Center.

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 9/15/2010 7:50 AM (GMT -7)   
Thanks very much for the link. The GI at the U of M is my doctor. Unfortunately we had to give amoxicillin to my daughter at one year, which I hated doing.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Reduced gluten and dairy.

Go Saskatchewan Roughriders!

Regular Member

Date Joined Jul 2008
Total Posts : 384
   Posted 9/15/2010 8:46 AM (GMT -7)   
This has always been something I wondered about. At 6 months of age, I was hospitalized with pneumonia. I was given tetracycline and developed the "gray teeth" that this antibiotic can cause in children. I also would have several ear infections when I was young and finally had tubes in my ears at age 4.
I started having crohn's symptoms around age 11-12, and dx'd at 14. I have often wondered if all the antibiotics I was on when I was younger had something to do with developing crohn's as a child.
Dx'd w/ Crohn's in 1979 at age 13. Bad flare 2008 but no health insurance so I dealt with it. Colonoscopy in July 2009 caused a perforated colon, emergency bowel resection. 2 fistula's, perianal and perivaginal.

Humira, probiotic, a multivitamin, Glucosamine, D3, calcium, potassium, magnesium, zinc, and fish oil. I also take Tramadol 50 mg and Klonopin (for anxiety) as needed.

Life may not be the party we hoped for, but while we are here we might as well dance!

Veteran Member

Date Joined May 2003
Total Posts : 2481
   Posted 9/15/2010 8:56 AM (GMT -7)   
I started giving my kids probiotics as soon as I learned about the benefits for my own CD.
Even while pregnant and breastfeeding with my baby, I took them, and alter gave my last baby Nestle Goodstart formula with probiotics..
I hate when I hear about kids with CD. That is the worst.

Post Edited (Roni) : 9/15/2010 10:09:17 AM (GMT-6)

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 9/15/2010 9:19 AM (GMT -7)   
I am the youngest of five and the only one in my family that has developed Crohns Disease. I had allergies bad as a child, and also had a ped doc who believied in getting the antibiotics into your system quickly and always injected them. I also started smoking at the age of 13 (now quit), and have always wondered if one of those things could be attributed to my developing CD. There are so many variables with this disease though that there is no telling what triggers it. JMHO
Gail*Nanners* Co-Moderator for Crohns Disease 
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined May 2003
Total Posts : 2481
   Posted 9/15/2010 9:51 AM (GMT -7)   
Nanners, I used to smoke too. Started at 12. Quit in early 20s.
Also had bad environmental and animal allergies from age 5ish. I was also allergic to milk when I was a baby and even had to be hospitalized because of it. I was a poor eater as a child and I remember having quite a bit of LRQ pain as a teenager - looking back, I know the CD was festering in there.
You and I have a similar story, except I have relatives diagnosed with CD.
Are you short too? lol

Regular Member

Date Joined Aug 2006
Total Posts : 443
   Posted 9/15/2010 10:52 AM (GMT -7)   
I think an equally possible explanation for the association is that children who one day go on to develop Crohn's may have more illnesses in infancy, and therefore are more likely to have been prescribed antibiotics at that age (meaning that the antibiotics are not the causal factor).

Regular Member

Date Joined Apr 2007
Total Posts : 345
   Posted 9/15/2010 11:03 AM (GMT -7)   
Actually my sister had antibiotics A LOT as an infant/toddler. . . She had tubes put in her ears. She did not develop Crohn's, i did.

I hope that isnt the case since my LO has had 4 ear infections this past (first) year of his life.
33 years old. Diagnosed in 2002ish. 
Taking Asacol, Lomotil TID, and on Remicade since 2004. 
Lower Bowel area only, except for the short stint (about 2 weeks) that I had mouth sores.  Also have external/anal fistula and anal/vaginal fistula. 

Veteran Member

Date Joined Jan 2010
Total Posts : 794
   Posted 9/15/2010 12:44 PM (GMT -7)   
I don't recall son having anti-biotics as a youngster or being sickly etc but he developed Crohns. Daughter was never off of them, she had three lots of grommets and her adenoids(sp) out yet she is clear of crohns(for the time being!!)
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