I'm in the same spot that you are... I've failed every other drug on the market. And... I just attempted to enroll in a GSK clinical trial for a new oral medication. It's a new mechanism and showed good responses on the Phase 2. Unfortunately, I have a couple of the exclusion criteria, so despite the fact that I meet every Crohn's requirement (had 9 vials of blood for labs, an EKG, colonoscopy, ... all to be told one day before my receiving my dose med, that I cannot participate. Not handling that too well, but that's for another post. This trial does have a 2 year
open label (no placebo), so it might be another option for you to look into.
So now that I've lost the trial, I have to choose between Stelara (hoping to get it covered) and LDN. My GI wants me to try LDN first. Mostly because it's so cheap that even if insurance doesn't want to cover it, it's something I can handle.
There are study results posted for LDN on the Penn State website (http://live.psu.edu/story/53494) (http://live.psu.edu/story/53494)
Maybe if you printed this out for your GI she might be more interested in helping you to try it.
The LDN study shows that it takes about
12 weeks to see a response. Stelara seems to show a response more quickly (http://www.drugwatch.com/news/2011/05/09/crohns-disease-treatable-stelara-psoriasis-medication/)
I'd love to keep sharing stories as it seems we are really at the same place right now. I am leaning toward Stelara. I suppose mostly because I have a lot of chronic pain and I am a bit scared to go without pain management for 3 months to see if the LDN works. but, if insurance won't cover the Stelara... then it's decided for me.