I take the same combo. The Methotrexate is painless when injecting, which is nice. Though it's intramuscular so it's slightly trickier to do the injection yourself (assuming you're doing MTX shots, not the pills).
I have so far had no trouble with MTX, though I often feel really tired after it. There are a lot of potential annoying side-effects though - luckily our does is small so they are less likely to occur. Good luck! I hope it works for you and I hope you handle it well with no adverse effects. :)