My doc decided to put me on methotrexate in order to be able to withdraw pred ( on it for a year now and all efforts to taper it off failed). I'm currently on Pentasa enema before bed, Pentasa tablets 2g, pred 7.5 mg (reached after a month of tapering). These meds were prescribed for a proctitis flare up. Even steriod enemas failed to make symptoms subside (persistent diarrhea). So, he insisted on my taking methotrexate 7.5 mg every Friday/8 hrs. Two of my friends who have cancer warned me against taking methotrexate and told me that it will increase fatigue (which is already there). Is this true of MTX? I've read that it should not be taken with folic acid (even if it's included in multivitaimins). I cannot live without taking a multivitamin every day and Ensure includes it as well. Is this correct? No folic acid whatsoever? What side effects should I expect?