Humira and Exhaustion

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Oct 2007
Total Posts : 390
   Posted 9/17/2011 2:41 PM (GMT -7)   
Does anyone who takes Humira find that that are exhausted the next day once they go to sleep? For example, I took my shot yesterday morning - fine all day, not a bit tired - then I go to sleep that night and slept for like 16 hours. This happens so often that I had to change the day I take my shot to Friday so it doesn't matter how long I sleep the next day but is this normal?

Regular Member

Date Joined Aug 2011
Total Posts : 299
   Posted 9/17/2011 3:03 PM (GMT -7)   
I had that initially, I took my last shot before bed instead of in the morning and I didn't feel as tired as previous shots.

I don't know if this is due to the timing or not but surely can't hurt to see
20 years old - female
Crohns dx 2009
Azathioprine 150mg, Asacol 3200mg, Ferrous gluconate 600mg, Humira bi weekly
Developed anti-bodies to infliximab.

Regular Member

Date Joined Apr 2009
Total Posts : 249
   Posted 9/17/2011 3:59 PM (GMT -7)   
I haven't had much of an issue with humira at all except for injection site reactions. I just started MTX and that kicks my butt...extreme fatigue, headaches, etc. Its hard to feel like that!! I have 3 kids that don't understand mommy's tired LOL

Regular Member

Date Joined Oct 2007
Total Posts : 390
   Posted 9/17/2011 4:53 PM (GMT -7)   
It's weird, I don't feel tired after I take it - but the next time I go to sleep it's like I am dead to the world. I went to sleep last night around midnight and woke up at 4:30 this afternoon! That is crazy. I've been on Humira for a year and a half and so it's not an initial reaction. I just thought someone else might have had the same expereience. When I was on Remicaide I would be tired for the rest of the day and the day after so maybe it's just something that effects me differently.

p.s. but seriously, 4:30 p.m.? I'm like a college freshman male!!

Regular Member

Date Joined Apr 2009
Total Posts : 249
   Posted 9/18/2011 8:51 PM (GMT -7)   
When I was on remicade I had the fatigue the same day and day after and was fine so thats not just you! Humira might make me fatigued but i have been dealing with low iron/ iron stores for the last 7 months and have had several iron infusions so I think its just not as noticeabl. The methotrexate is kicking my butt like Remicade did though!!
ulcerative proctitis diagnosed October 2007
As of 11/11/10 - I have inflammation and ulcers in my terminal ileum (ileitis). Now saying I have indeterminate colitis since I have UP and now ulcers in my ileum. Could have crohns...who knows!

Current Meds:
Humira shot every week
MTX 1 shot/week
Meds that don't work/don't take anymore:

Pyroclastic Flo
New Member

Date Joined May 2011
Total Posts : 10
   Posted 9/18/2011 9:23 PM (GMT -7)   
Yep. I call it the Humira hangover. It doesn't really matter what time of the day I do my shot, I can bet the next morning is going to be a rough one. It always feels like I'm coming off an all-nighter. The only thing that I've found that somewhat helps(although it may be purely psychological) is taking it earlier in the day(before my last meal), and drinking plenty of water before and after. about the same thing you would do to try and avoid a regular hangover lol. Lately with me I've been experiencing fatigue throughout the week and also pretty bad episodes of shortness of breath. Don't know if it's Humira related, but can't think of anything else I would attribute it to. Anyway, good luck to you. Hopefully it gets better.
Male 32 y/o
Diagnosed in 2002
Have been on Pentasa, Asacol, multiple runs of Pred, and presently Humira with Lialda.
No surgeries

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 9/18/2011 11:28 PM (GMT -7)   
Hi I have been on Humira for over 5 years and I am fine. I am not tired
the next day. The next day is just fine for me.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on and Humira. B-12 injection once a month.
Also diagnosed with Rheumatoid Arthritis.

Regular Member

Date Joined Jan 2010
Total Posts : 265
   Posted 9/19/2011 11:14 AM (GMT -7)   
Well... usually I am tired in the same day. But I do find it's harder to leave the bed in the next day.

But not big deal. In the lant month I played golf, all the 18 holes in the next day. And, as I am still a beginner, it took me 125 swings to finish the course!
Male, 36 (lovely family of wife and two daughters)
Diagnosed in nov/94 - Started with Prednisone, followed by Pentasa, entocort, flagyl, Imuran, etc.
Blockage (popcorn!!) - First Surgery 2001 (no ressection)
Severe bleedind - 2003
Stricture leading to a ressection in Dec/2008 - Second Surgery
Blockage due to adhesions - Third surgery in feb/2011
Now going off Remicade and back to pred

Regular Member

Date Joined Oct 2007
Total Posts : 390
   Posted 9/21/2011 8:34 PM (GMT -7)   
Pyroclastic Flo said...
Yep. I call it the Humira hangover.

THAT is hysterical. I'm glad to hear other people experience this, like I said when I was on Remicaide I would be so tired that day and would usually fall asleep in the chair - that could have been due to the xanax I would take beforehand and the benadryl they would sometimes have to put in my IV - then the next day I would be kind of lethargic. But with Humira I am seriously fine all day then that night when I go to sleep I am down for the count. I know it helps and i'm thankful, but I have to wonder what I am putting in my body...............

I haven't updated my signature in a while but I am 35 yr old girl w/ Crohn's Colitis - dx in 2006, was on 6mp, Remicaide and now Humira. I was vegan for a while and was so good about taking all my herbal supplements and vitamins and doing yoga everyday and running and instead I have traded it in for a stressful job and haven't been doing many good things for my body lately. I need to start because, although last year I didn't get sick (knock on wood) it was the first cold weather season that I didn't and now that Fall is upon us...............

This is totally another thread but does anyone taking Humira get sick more often in the Winter as opposed to the Summer months?

Regular Member

Date Joined Mar 2003
Total Posts : 73
   Posted 9/22/2011 12:58 PM (GMT -7)   
Funny, I was just going to post a topic about If Humira is causing you to be fatigued?

I have been on Humira for just over a year, and my energy is about 70 percent. That is until last week, my energy is very low, have talked to my G.I. about it and all my blood work is fine. This past week I feel so fatigued. Not sure if I should be looking at something else but Humira. Has this happened to you other than the day of or after your injection?
Crohn's since 1997, 1 bowel ressection in 2004. Meds: Immuran, Questran, Humira, Vitamin B12, Palafer, Vitamin D, Multivitamin, and Calcium. Buscopan and Tylenol #3 as needed.

New Member

Date Joined Jul 2012
Total Posts : 0
   Posted 7/17/2012 7:19 PM (GMT -7)   
Hi... I'm new to this site and have just had my 2nd Humira injection for Ankylosing Spondylitis. I have noted a reduction in my pain levels and found I was sleeping more soundly after my first injection.

However, I have found Extreme Exhaustion with the Humira. After my first injection it was the day after and then a further day which virtually became a wash out. With the second injection about 5 days ago, I have been feeling almost continual exhaustion... I have no doubt it is from the Humira. Whilst giving benefits of one respect, it is taking it's toll on me in another. I will be having to weigh out the benefits vs the risk factors with both my doctor and rheumatologist.

Thank you for all others who have shared this complaint as it is good to know one is not alone ..

Post Edited (2bpainfree) : 7/17/2012 8:24:31 PM (GMT-6)

Regular Member

Date Joined Jun 2003
Total Posts : 418
   Posted 7/19/2012 5:44 PM (GMT -7)   
Yes, that is exactly it. Not the day of the shot but the next day. It's so bad that others notice how terrible i look and how fatigued I am. It's like the flu. But then hey the next day after that I feel great.

New Member

Date Joined Dec 2014
Total Posts : 2
   Posted 12/17/2014 5:03 PM (GMT -7)   
Trying to find more folks who have had severe fatigue and nausea on humira. My 11 year old Crohnie has been on humira post jejunal resection for almost 2 years, starting in August, he was having bad nausea (not unlike his flare symptoms - he has upper and small bowel CD) and it got worse after his gastro increased his dose to 40mg every 2 weeks. He has been out of school with the nausea since Halloween. He is in a solid CD remission, so I am hoping the symptoms are all about humira side effects? Today he slept all night and then all day too! Scary stuff. How long til he feels better if we stop today (he is due today) - this is against his gastros advice. She is not happy that he is going off but I feel we have no choice.

Veteran Member

Date Joined Mar 2005
Total Posts : 1289
   Posted 12/19/2014 2:30 AM (GMT -7)   
Yup. The day after my shot I am sometimes so tired I can't keep my eyes open- literally. It's awful
40 year old male living in AZ. Diagnosed with Crohns at age of 15.
Currently on 15 mg prednisone, Asacol HD, Humira, imuran
Feeling up and down for a while now...

New Member

Date Joined Dec 2014
Total Posts : 2
   Posted 12/26/2014 12:07 PM (GMT -7)   
He has chronic nausea and fatigue, all the time - not just after the shot. He sleeps 17-20 hours a day, every day. Could this be from Humira?

Regular Member

Date Joined Apr 2010
Total Posts : 81
   Posted 1/16/2015 4:48 AM (GMT -7)   
I started Humira 3 months ago, and I feel really tired all the time, I could sleep all day long! My blood tests are fine, Humira is starting to work I think (very slowly), it's the first time I'm able to taper pred, but I don't have the energy to do anything. Hope it passes, cause I'm 41 years old and feel like 80.
New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, November 17, 2017 5:32 PM (GMT -7)
There are a total of 2,894,916 posts in 317,747 threads.
View Active Threads

Who's Online
This forum has 157353 registered members. Please welcome our newest member, goalkeeper.
372 Guest(s), 6 Registered Member(s) are currently online.  Details
SomeonesMom, BJD55, gfields, Organicmommy, AZ Guy, Blu's Mama

About Us | Advertise | Donate
Newsletter | Privacy Policy & Disclaimer
Follow on Facebook Follow on Twitter Follow on Pinterest
©1996-2017 LLC  All Rights Reserved.