stopping Humira

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New Member

Date Joined Apr 2012
Total Posts : 4
   Posted 4/4/2012 1:15 PM (GMT -7)   
I've been taking Humira for the past 2 years. I recently as of 4 days ago stopped taking the medication due to the side effects were getting to me and the medication just stopped working. My doctor said I will most likely have withdrawal symptoms. Anyone have them and can explain the symptoms please? Also, I might switch to Remicade. Anybody go from Humira to Remicade and like it better? I am scared of the side effects Remicade will have and does it cause weight gain too? Humira made me gain 20lbs. I don't want to gain more weight.....Please help!

Regular Member

Date Joined Nov 2011
Total Posts : 360
   Posted 4/4/2012 6:37 PM (GMT -7)   
Humira & Remicade doesn't really cause weight gain, I think. You probably gained weight because it was helping you absorb food better & when ya feel good, ya eat more!

Hope ya feel better & find the right meds :)
Current medicine:Humira, Prednisone, Apriso,Zantac, Prilosec, Probiotics, Folic acid, B-12, fish oil, D-3, Zinc supplements, Nortriptyline, tramadol, phenergan, Antivert, zofran, lortab, flexeril.
Previous meds: Way too many
In current flare since: Feb 2011
"I have Crohn's Disease. Your excuse is invalid." :)

Veteran Member

Date Joined Jan 2003
Total Posts : 6143
   Posted 4/5/2012 2:27 AM (GMT -7)   
went the other way with no problems. no weight gain for me if anything a loss. untill i hit the steroid bottle heavy. side effects i had when i quit the humira before were just joint pain that roamed the knees and elbows and wrists and fingers. ;o)

New Member

Date Joined Apr 2012
Total Posts : 4
   Posted 4/5/2012 10:45 AM (GMT -7)   
Thxs for your responses. So far just a few headaches, irritable and tired!!!! I'm sure the real side effects won't hit me for another month if I have a flare up from going off. I do have a prescription ready for Entocort just in case if a flare up.

Regular Member

Date Joined Apr 2007
Total Posts : 208
   Posted 4/6/2012 5:48 AM (GMT -7)   
Actually, biologics can make some gain weight. There's quite a few articles online about research results that do show weight gain. It doesn't cause it in everyone and they're not sure why it happens. I took Humira, Cimzia, and Remicaid. Hoping to go back on Cimzia soon. I like the convenience of doing the injections at home. The Remicaid infusions take too long and aren't nearly as convenient. I'd love for that to come in syringes : )
Meds: zoloft, gabapenten, lisinopril, zyrtec

Crohn's Disease with a failed seton placement for fistula, 2 perforations, 1 small bowel resection. Technically in remission, but still feel sick. Have joint pain, muscle pain, fatigue, nausea, D, and abdominal pain & cramping; recently diagnosed with Crohn's arthritis and gastritis.

New Member

Date Joined Apr 2012
Total Posts : 2
   Posted 4/24/2012 2:06 PM (GMT -7)   
Hi Jaye
Good Luck with your use of Humira, I do not want to sound like I am bashing the treatment but it is causing me problems with weight gain.  Since my use started (March/2012) I have steadily gained weight!  This is a side effect that I dont want or need.  I thought I was going nuts here, as I started working out most recently and have not increased my portions but my weight sure have gone beware!  As I am one patient that has encurred the opposite results of the medicine.

Regular Member

Date Joined Dec 2010
Total Posts : 62
   Posted 4/28/2012 2:05 PM (GMT -7)   
I stopped Humira in January, because of Crohn's Arthropathy. Been on predisone 10 mg daily to bring down the swelling and extreme pain in the joints, muscles and tendons. Still using the bath room way too many times daily, 15 - 17, chronic diarrhea. Wish you well, you should not gain weight stopping Humira, it may do the opposite.
Diagnosed with Crohn's '04, 14 inch colonresection '04, Gangrene of Gallbladder D/T CD '05, Repair of Abdominal surg. sight,'05, Lithotripsy for Kidney stones due to CD, Crohn's returns in Ileum Started Remecade, reaction to Remecade in 6mo., 6 mo of steroids, Started on Humira, Colozal, Percocet, Xanax, Total of 21 meds for other conditions. Diabetes, etc. Chronic pain All Joints.

Veteran Member

Date Joined Jun 2009
Total Posts : 586
   Posted 4/29/2012 10:50 AM (GMT -7)   
I, too, and switiching from Humira to Remicaid, but my doctor never metnioned anything about withdrawal symptoms. If it is not working anymore I don't think you will notice much of a difference once you stop taking it. I never noticed any weight gain on Humira, and it helped me achieve full remission for almost 3 years (I am now flaring due to the birth of my son). I know different people react differently to medications, but my GI did mention that if you do well on one biologic, you tend to do well on all of them. Fingers crossed for you!

Regular Member

Date Joined Aug 2009
Total Posts : 90
   Posted 4/30/2012 3:37 AM (GMT -7)   
Mmm I was never told of withdrawal symptoms either. What side effects of Humira are bothering you? about six months ago I switched from remicade to humira because the remicade was causing drug induced lupus. Humira seems to be working well for the crohns but they have added prednisone temporarily to help with the arthritis, looks like the next step is Imuran. I really liked Remicade, and even tho it was a pain to go get the infusion, I like meeting and talking with other people thave Crohns. It was nice to meet others. And it evenmakes you appreciate how blessed you are because a lot of others have had a much worse time. It really put things into perspective for me, meeting a man who didn't have options of biologic agents like we do now, like many in this forum. The surgeries for resection were and still are so risky, this particular man had so many resections, so much pain, so thin and pale, he looked like a young teenager but he was in his 30s, it was tragic. I'm lucky to have met him :)

New Member

Date Joined Nov 2016
Total Posts : 1
   Posted 11/24/2016 7:24 AM (GMT -7)   
I recently switched from Humira to Remicade Remicade is barely doing anything but they are going to up my dosage soon since I'm on the last one I have been experiencing arthritis-like pain in both of my wrist and thumb joints sometimes in my knuckles as well this morning I have an angle hurting and I I'm in enough pain in my right hand that I'm sending hubby out for a brace... it started about two months ago but it was very infrequent and now it's every other day.
I found this forum because something told me it has to be related to the fact that we were taking medication that is for rheumatoid arthritis coming off of it is definitely going to cause withdrawals for our bodies but it's nice to know I had no idea it was coming like I needed to add another Health concern to the list ****

New Member

Date Joined Sep 2017
Total Posts : 1
   Posted 9/18/2017 5:02 PM (GMT -7)   
I am feeling very blessed after reading the post. I was told back in 06 that I had Crohns. I had one flair up back in 2015. I had another beginning of this year that was really bad. I spent 8 days in the hospital. I was only on 1 drug (Balsalazide) at the time, now I am on that plus Humira. I have not noticed any difference being on the 2 drugs. I do have a new skin problem being on the Humira. I came to read the post because I am thinking about stopping the Humira. I believe I will stay on it a while longer until I am 100% certain. I read Crohns is a stress disease, I had a lot going on around the first of the year when the flair up happened. I had just accepted a new position on my job that took me from first shift to second, and I had just sold my house. Feeling much better, I have never had the pain I hear about with Crohns. The arthritis thing is new, I have a pain in my right side around the hip area. I just turned 56 in August so I am sure some of the arthritis is due that as well. My doctor is quick to write a prescription so I have not learned to trust her yet. Good to have a forum like this, glad I found it. Lets hold each other up in pray.

New Member

Date Joined Jul 2011
Total Posts : 14
   Posted 9/20/2017 8:15 AM (GMT -7)   
I am about to go off Humira (have been at 80mg/week) and I am switching to Stelara (sadly, I developed an allergy to Remicade years ago, have antibodies and it's not an option). I also just added Imuran (prior to switch to Stelara), so I'm hoping that's the duo I need.

I haven't heard about any side effects of going off Humira, other than the chance that it was having some therapeutic value and your new treatment isn't as effective or hasn't ramped up. My doc and I are figuring out the best way to time the transition to hopefully avoid any backslides.

Best of luck to you!
Diagnosed with Crohn's: 2002
Past Meds: Pentasa, Remicade, Cimzia, Asacol, Cipro, Flagyl, Lialda, VSL#3
Current Meds: Humira (80mg/week)

Surgeries: Fistulotomies & Seton Placements/Adjustments (September 2011, January 2013 & August 2013); Advancement Flap (December 2013); Temporary Loop Ileostomy (July 2016); Fistula Repair with Gracilis Muscle (September 2016); Fistula Repair (December 2016)
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