Whether MAP is the cause of Crohn's or not, triple antibiotic therapy has little value in treatment. After TWO YEARS on an antibiotic cocktail specifically designed to combat MAP, the control group was faring considerably better than the group taking the drugs. From:
At week 16, there were significantly more subjects in remission in the antibiotic arm (66%) than the placebo arm (50%; P=.02). Of 122 subjects entering the maintenance phase, 39% taking antibiotics experienced at least 1 relapse between weeks 16 and 52, compared with 56% taking placebo (P=.054). At week 104, the figures were 26% and 43%, respectively (P=.14). During the following year, 59% of the antibiotic group and 50% of the placebo group relapsed (P=.54).
Using combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for up to 2 years, we did not find evidence of a sustained benefit. This finding does not support a significant role for Mycobacterium avium subspecies paratuberculosis in the pathogenesis of Crohn's disease in the majority of patients. Short-term improvement was seen when this combination was added to corticosteroids, most likely because of nonspecific antibacterial effects.
This has not stopped the MAP = Crohn's crowd from pushing these drugs on patients despite the serious side-effects caused not only by long-term consumption of antibiotics, but from little things like how clofazimine leaves crystals in your organs, and (for 75-100% of patients) turns your skin pink to brown- and it may last for years.
Even if these antibiotics were to treat MAP, what of it? You'd need to be on these drugs the rest of your life if, as the MAP crowd claims, MAP is pervasive- found in milk products, found in the drinking water, and so forth. You'd run the risk of re-infection, even if you were to somehow clear MAP from your body.
The entire MAP=Crohn's hypothesis doesn't jibe with the data. While for TNF drugs the most absolute contraindication is infection, Crohnies get better on TNF drugs. If MAP is caused by an infection, you'd expect to see people get worse on Humira and Remicade, not better. Ditto with immunosuppression drugs that are routinely prescribed for Crohn's. And the MAP crowd explains this away with special pleading, but what they cannot answer is why enteral and total parenteral nutrition succeeds in managing Crohn's. If MAP causes Crohn's, why does the luminal contents of the intestine even matter? MAP is a facultative intracellular pathogen, and cares not whether one consumes a cheeseburger or a salad or a can of Modulen IBD- but a portion of Crohnies do substantially better on enteral (canned) diets, with a similar proportion doing better on total parenteral nutrition.
Be wary of doctors foisting high-dose exotic anti-mycobacterial drugs upon you. The published data in the peer-reviewed, refereed literature does not support their use. If they offer anecdotes ("Well, we have one patient who has been in remission for _X_ years on these drugs"), back away slowly and leave as they are offering nothing but rumors and false hope while using you as a guinea pig at your expense.