I can totally relate to how you feel about taking the major step to some of these highly advanced medications.
I have a 20yr. old Daughter, and we/she was in very much the same boat that you're in some time ago. Minus the RA.
We had a terrible fear and apprehension about going onto Remicade/Imuran. We read all the horror stories, and it was such a tough decision.
The thing you have to consider first off is, if you don't get this disease under control, it can cause irrepairable harm to you body. The more it's allowed to rage unchecked, the more permanent damage it's going to cause.
You also have to consider that alot of the extreme negatives in regards to anti-tnf's, are in just as extremely small numbers. Very small percentages have contracted T-cell Lymphoma, and predominantly in teenage boys. I'm not trying to say I'm some kind of expert, just that you have to try to be very objective in making this decision, and make an educated decision for yourself, not a decision out of fear.
Believe it or not, the use of Prednisone repeatedly, could very likely cause alot more problems in the long run for you than the use of Remicade/Humira.
In my Daughters case, she was at rock bottom. She had been taking Imuran for 2 yrs. and it wasn't working. She developed multiple fistulas, considerable scarring, the disease was given the opportunity to spread into her large intestine. She's now been on Remicade/Imuran for about 7-8 months. So far she's thriving. The Remicade seem to start working almost immediately.
Are we still worried, of course we are. Worried about the side effects long term, and worried abouit the disease. But for now it seems like it was the best decision we could have made.
Good luck with whatever you decide. Please keep us posted.