C. Diff. vaccine

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scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3449
   Posted 1/29/2014 9:46 AM (GMT -6)   
I received an email today from Center Watch, which monitors clinical trials all over the country. You can sign up for alerts about conditions and locations that you might be interested in.

This email is for a trial for a vaccine for c. diff. This one is located in San Antonio, but they might have more across the country. Anyway, just thought I'd share for anyone who might be interested!

centerwatch.com/clinical-trials/listings/studydetails.aspx?Studyid=193032
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade, omeprazole
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8384
   Posted 1/29/2014 9:55 AM (GMT -6)   
How are you doing today?
*******************
50 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day)generic Colazal (96 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (1/2T daily), mesalamine enema as needed. Gluten free as of 5/30/11. Colonoscopy found no evidence of inflammation on 8/16/1

pmedic
Veteran Member


Date Joined Nov 2009
Total Posts : 1682
   Posted 1/29/2014 10:22 AM (GMT -6)   
As soon as this is on the market, I will be first in line. C-diff is the devil! I would not wish this crap on my worst enemy.

How are you feeling? Are you out of the hospital?

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3449
   Posted 1/29/2014 12:19 PM (GMT -6)   
Yeah, c. diff. is pretty crummy.

I'm doing a bit better. Still in the hospital because of the blood clot with all these blood thinners. Not sure when I'll get to go home, but it's ok because I am able to keep getting the IV anti-fungals without having to go to the infusion center every day and get stuck (they won't let me get another PICC). Plus the ladies who are watching my baby bring her to the hospital every day for several hours, which has been really nice for both her and me. The thrush is getting a ton better, and we're hoping it'll clear up for good this time. If they go to release me and I'm still having some thrush symptoms, then I'll continue at the infusion center. But I am going to keep pumping for now. If the thrush comes back this bad again for a third time, then I'll most likely stop. But you can't just quit cold-turkey or you run the risk of severe mastitis, especially with how much of a supply I have (I pump over 40 oz each day with only 5 pumps per day). So if I were to stop weaning this close to the thrush being cleared up again, then I'd probably kick myself later!
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade, omeprazole
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8384
   Posted 1/29/2014 12:40 PM (GMT -6)   
Yeah, I was thinking back to when I was pumping and breastfeeding. A gradual wean is always the best. With that in mind, have you considered night weaning?

I had a terrible oversupply problem with my first daughter that left her very colicky. I had to reduce my supply and the best way to do that without skipping a feeding is to simply feed one side only at each sitting. I had to pump just to relieve pressure on the un-drained side, but I was able to reduce supply pretty effectively this way without getting mastitis.

I did a similar thing when I night-weaned my 2nd child. She nursed full time well into her 3rd year of life and I was losing a lot of sleep. So we cut waaaaay back on her night time feeds, first by just reducing the duration of her nursing sessions. I think you could do the same with the pump. Gradually shorten each session until you feel like you can then space them out. If you night-wean you can get more continuous and healthy sleep. I'm pretty sure you have a stash of frozen milk that will keep your daughter fed for weeks if not months.

I'm glad to hear your fungal infection problems are getting better and I hope they stay far away from now on!
*******************
50 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day)generic Colazal (96 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (1/2T daily), mesalamine enema as needed. Gluten free as of 5/30/11. Colonoscopy found no evidence of inflammation on 8/16/1

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3449
   Posted 1/30/2014 5:16 AM (GMT -6)   
Thank for the insight on weaning! I've been trying to think of how to do it. I actually only pump 5 times a day, and really not at all during the night. I pump at 4a (then go back to sleep), 8a, noon, 4p, and 8p. So I think shortening the pumping time is going to the most effective way to start cutting back at first. But I think I'm going to see if the thrush clears up first. :)
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade, omeprazole
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8384
   Posted 1/30/2014 8:53 AM (GMT -6)   
If you would consider doing a short pumping at 10 pm, right before bed, and then wait until 6 or 7 am for your morning pump, you probably won't even see a dip in supply. Morning hours are when prolactin is at its peak and your supply will be abundant. I'll bet you can do a 6 am pump and then again at 9 am and you may even see an increase in your stash.

Cabbage leaves are a well-known way to reduce supply. If you have to do a quick reduction in lactation that is the way to go, but it sounds like you are not there yet.
*******************
50 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day)generic Colazal (96 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (1/2T daily), mesalamine enema as needed. Gluten free as of 5/30/11. Colonoscopy found no evidence of inflammation on 8/16/1

pmedic
Veteran Member


Date Joined Nov 2009
Total Posts : 1682
   Posted 1/30/2014 7:20 PM (GMT -6)   
Glad things are improving! I can only imagine how hard this has been for you!

Sending more prayers your way!
Dx:Ulcerative Colitis March 2008
Dx: Crohns May 2008
Avascular necrosis bilateral knees from Prednisone. Surgery on left knee was Oct 2011, Right knee April 20138 blood transfusions, SVT due to low H&H, Anxiety during new medication injections due to past reactions. C-diff, pancreatitis from metabolic acidosis from medication.Currently on Lialda, Ambien, xanax(prn) D3, probiotic, Rowasa, Cimzia

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3449
   Posted 1/31/2014 12:12 AM (GMT -6)   
Thank you!! :) @kazbern, I'll have to give that a try, thanks!
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade, omeprazole
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8384
   Posted 1/31/2014 7:16 AM (GMT -6)   
Your breasts will probably wake you at 4 am if you try this. If you feel a lot of pressure express just enough milk to get comfortable. After a couple of nights your body will adjust.
*******************
50 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day)generic Colazal (96 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (1/2T daily), mesalamine enema as needed. Gluten free as of 5/30/11. Colonoscopy found no evidence of inflammation on 8/16/1

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3449
   Posted 1/31/2014 1:10 PM (GMT -6)   
Wow, I spend too much time on facebook - I just tried to "like" your comment, @kazbern! :) Before I change times, I will need to see what my baby's schedule is like (my husband told me it's changed a bit while I've been sick). The times I listed above fit perfectly in between her feeding and nap times, which is part of why I set them up that way.

Still in hospital, though. My blood just doesn't really want to thin out. I am really hoping tomorrow the labs will hit the magic number!
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade, omeprazole
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33
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