You might restart Humira with no troubles at all, you might have troubles, no knowing for sure. You've got increased odds of developing antibodies after stopping Humira but it is far from a guaranteed outcome. Try and see. Worst-case scenario is you switch to another TNF-Alpha blocker like Simponi (which is a sister to Humira).
Some of us develop antibodies despite following the very best known practices. Some of us never develop antibodies despite never following best recommendations. There's a bit of randomness and unexpectedness to it all. It's believed that antibodies are most likely to happen when first starting a biologic (why it's often started when you're concurrently on MTX/imuran/6MP) and after stopping the medication. This is not 100% known though, just leading beliefs.
For all practical purposes, Humira/Remicade looks like a virus to our immune system. Why? Viruses and biologics are complex proteins introduced into our bloodstream. You contract a virus and our immune system immediately tries to develop antibodies, stop it, and protect us. After a virus runs its course and we get better, the immune system begins developing antibodies to it by locking on to and figuring out the various dead, weakened, and dying virus pieces floating around in our bloodstream. That's how vaccines work, we get a shot of dead or live but weakened virus, our immune system detects it and rushes to make antibodies for it.
Technically, Humira is a bit less likely to cause antibodies than remicade. Why? Remicade is made from a mouse-cell line and the protein makeup of the remicade proteins is ~25% foreign and therefore the immune system is more likely to target remicade proteins as foreign invaders. Humira is newer, and is 100% humanized without the foreign proteins which makes it less of a target. Humira antibodies can still develop and do for some folks. We don't know the exact mechanisms or reasons, nor can we predict who is more/less likely to develop antibodies than others with any degree of accuracy. Cross your fingers and hope for the best!
Moderator Ulcerative Colitis
John, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasaBoss makes a dollar while I make a dime and that's why I poop on company-time...
Post Edited (iPoop) : 2/16/2018 7:53:47 AM (GMT-7)