What is the difference between those who get Crohn’s and those who do not?
It actually comes down to a form of Immune Deficiency; our bodies have several levels of defences against invading bugs. The most basic defence cell is called a ‘macrophage’ -it is a type of white blood cell which behaves a bit like ‘pac-man’! It patrols the body eating up and digesting any invaders. Then there are the more sophisticated ‘T-cells’ – another type of white blood cell, specifically designed to defend us against bugs which hide INSIDE cells in the body –like MAP does.
When healthy people are exposed to MAP, their macrophages gobble up and digest MAP and their T-cells ‘see’ and eradicate any MAP-containing cells. They may retain a few isolated bugs but they never get sick. When someone susceptible is exposed to MAP, it is a different story. Their macrophages eat MAP but cannot digest it and MAP remains, happily living inside the macrophage. In addition, their T-cells are ‘blind’ to MAP; they cannot eradicate it and MAP is allowed to multiply unchecked, generating vast numbers of organisms inside the gut as well as other tissues (even inside the T-cells themselves). This is the person who develops Crohn’s Disease.
How does MAP actually cause disease?
MAP itself does not directly cause gross inflammation by taking on the immune system head-to-head. In fact, MAP minimises its own immune recognition. Instead it initiates a cascade of events with disastrous consequences. The first is to cause dysregulation of the immune system which then destabilises the gut wall, rendering it leaky. Leakiness of the gut wall allows it to be penetrated by other gut organisms (e.g. bacteria such as E.coli, yeasts and viruses) and irritant food residues. It is these secondary invaders and irritants that cause the massive inflammatory response which creates the Crohn’s pathology. The second is to damage and inflame the delicate nervous system in the gut wall which makes the consequences of the immune dysregulation a lot worse.
Immunosuppressants can reduce Crohn’s symptoms by lessening the inflammatory reaction in the gut wall (some may also possess some direct anti-MAP activity). Antibiotics like metronidazole can reduce Crohn’s symptoms by killing off other bacteria which invade the gut wall. Bland diets can reduce Crohn’s symptoms by removing some of the irritants which trigger more inflammation, but unless you treat MAP itself, you are only treating the mechanism and not the cause of Crohn’s Disease. That is why we need this therapeutic and preventative modern Vaccine.
Taken from this link....
DX with Crohn's Disease in 1991 shortly after becoming ill. CD was affecting small and large bowel & anus (perianal crohn's skin tags) & rectum for first 2 yrs of becoming sick, CD remained constant in colon (Crohn's colitis) & anus with anal tags, intolerant to oral meds. Currently on Humira (Feb 2014) once a week and B12, Vitamin A and Omega's daily. In remission but trying to combat IBS D/C.
Post Edited (pb4) : 1/10/2016 10:21:04 AM (GMT-7)