Literally the only improvement I got was after my first infusion. It wasn't dramatic but I definitely felt better. Not to be depressing, but subsequent infusions were like having saline infusions for all the effect they had.
I think if I'd had started Remicade a few years earlier, it would have been more effective. I'd been walking around with severe pancolitis for years before I finally got onto a biologic, by which time it was obviously too late. My hospital seem determined to repeat history, but I really am in danger of going woefully off-topic, so I'll shut up now.
Dx Crohn's in summer of 2000. (Yay )
Tried and failed: 5-ASAs, azathioprine, 6MP, Remicade, methotrexate, Humira, various diets.
Had surgery Feb '13 - subtotal colectomy with end ileostomy. First thing to put me into remission in 13 years.
Had second surgery 10th July '15 to reverse the stoma and connect the ileum to the rectum. Officially flaring again. The fun never begins.