humira pregnancy?

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November15
New Member


Date Joined Aug 2017
Total Posts : 1
   Posted 8/25/2017 3:48 AM (GMT -7)   
Hello everybody, I'm 43 yrs old living in Athens, Greece. I've been suffering from Crohn's the last 18 years, and I've been through hospital stays many many times, until I started humira 2 yrs ago, which gave me my quality of life back.
I already have two beautiful daughters 21 and 17 yrs old from my first marriage, and my second husband has two beautiful boys 15 and 12 yrs old, their mother died unfortunately almost 10 years ago...
Since we already have 4 children, having a baby of our own is not a priority but I keep thinking what if that happens??? and I'm on humira? I mean being 43 is a high-risk pregnancy anyway, but if you add the humira on top...
Any throughts or experiences with humira and pregnancy??
Much appreciated!!
All the best from sunny Athens

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3319
   Posted 8/25/2017 5:46 AM (GMT -7)   
Welcome to the forum, congratulations!

I haven't been on Humira, but I've had two pregnancies with Remicade, which is a very similar drug. With both pregnancies (done across three different states with three different sets of OBs and high-risk OBs) the consensus is that it's best to stay on the medication the entire pregnancy. It does get into the baby a bit, but it doesn't cause any harm. The baby will be born with a small amount of the medication in their system, but as long as you keep the baby away from the public for a couple of months (which you should kind of do anyway), and don't do any live vaccines for the first year (which in the US is only the rota-virus), then you should be just fine. And since Humira doesn't stay in the system as long as Remicade, I imagine that it's even safer. The study he referred to for all of this is the PIANO study, I believe is what it's called.

My GI mentioned to me that Entyvio (I *think* that's the medication he said) doesn't cross the placental barrier at all, so it should be even better if you want to switch to it. I was already about 5 months along with my second, so I didn't feel comfortable switching in case it didn't work or I flared or something while pregnant.

Also, with regards to breastmilk, the proteins for Remicade (and I am assuming Humira) are too large to get into breastmilk, so it's completely safe to nurse/pump after childbirth.
"For this thing I besought the Lord thrice that it depart from me. He said, My grace is sufficient for thee: for my strength is made perfect in weakness. Most gladly therefore will I rather glory in my infirmities; I take pleasure in infirmities, reproaches, necessities, persecutions, distresses, for when I am weak, then am I strong" 2 Cor

straydog
Forum Moderator


Date Joined Feb 2003
Total Posts : 15315
   Posted 8/25/2017 7:55 AM (GMT -7)   
It has been a long time since I looked on Humira's website so I looked. All it says is if a person is pregnant, planning on getting pregnant & plan to breast feed to discuss it with the dr first. I know that several here have had Remicade babies & did fine. If you are considering getting pregant, I would discuss it with your dr.

Take care.
Susie
Moderator in Chronic Pain & Psoriasis Forums

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 11022
   Posted 8/25/2017 8:25 AM (GMT -7)   
Here's a couple links that talk about biologics and pregnancy. Generally, you would be fine, as many moms have had happy and healthy babies despite being on biologics (humira, remicade, etc.).

From conception to delivery: Managing the pregnant inflammatory bowel disease patient
www.ncbi.nlm.nih.gov/pmc/articles/PMC3974516/

The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease
ecco-jcc.oxfordjournals.org/content/eccojc/9/2/107.full.pdf
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g Lialda, and 2X rowasa

I suffer from heinous anus
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