White blood cell count under threshold for Mercaptopurine...

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Date Joined Jun 2017
Total Posts : 14
   Posted 9/10/2017 12:03 PM (GMT -7)   
Hey guys,

Just a quick question, I got a voicemail from my doctor on Friday ( I couldn't answer my phone as I was at work). He called to tell me my monthly bloods for September indicated my white blood cell count was under the 4 threshold for Mercaptopurine. He told me to stop the medication over the weekend and he would speak to my GI team on Monday.

I was wondering if any of you knew what this meant as he didn't really explain it well and I'm a bit confused with it all confused


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Date Joined Nov 2003
Total Posts : 7122
   Posted 9/10/2017 3:45 PM (GMT -7)   
Mercaptopurine can cause the white cell count to go down. It is an immunosuppressant, meaning that is its intended purpose. Sometimes it can cause the WBC count to go too low. That is why the doctor told you to stop it. Usually the WBC count returns to within the normal range fairly quickly.

I had this happen when I was first put on Imuran, a cousin of Mercaptopurine. My WBC count was 2.1 and it returned to the normal range in a week. I was able to resume the medication and had no further incidents of low WBCs.
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New Member

Date Joined Jun 2017
Total Posts : 14
   Posted 9/10/2017 3:56 PM (GMT -7)   

Thanks so much for responding. I knew it could do lower your white cell count, but the meds have been fine until now, so I was just a bit confused I guess.

Crohn's medications certainly don't come without issues!
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