Have you ever taken Remicde + Imuran?

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New Member

Date Joined Jun 2014
Total Posts : 11
   Posted 9/17/2017 4:57 AM (GMT -7)   
Hello all,

This is a longwinded question, so please bear with me.

I've been taking Remicade for many years. Recently, my doctor added Imuran to boost the effectiveness of the Remicade. My crohn's symptoms are stable (yay) but now I'm dealing with immense fatigue and depression. I've spoken to my doctor about it and he says it's not the Imuran that's causing this.

Of course, our doctors are not always right, are they? Has anyone else experienced what I described above?

Thank you in advance.

Veteran Member

Date Joined Mar 2007
Total Posts : 1653
   Posted 9/17/2017 1:19 PM (GMT -7)   
I haven't taken Remicade, but I did try imuran - and it made me really tired & nauseous. So I don't think it's a stretch that it could be affecting you.

As you may know, it's not a good idea to start and stop Remicade - you increase your risk of developing antibodies.

But there's no issue with starting and stopping imuran. So if I were you, I'd talk to the doctor about stopping the imuran for a few weeks and see how you feel. If you feel a lot better, it might be the Imuran. Then you could try it again. If you start feeling bad again, you'd have pretty good evidence its' the Imuran. If not, you'll know it's not the imuran.

By the way, how much imuran are you taking?

Veteran Member

Date Joined Mar 2007
Total Posts : 1775
   Posted 9/17/2017 5:53 PM (GMT -7)   
Adding another immuno like Imuran while on biologics is a very common approach now. Combination therapy was introduced, as evidence showed that it reduced the likelihood of developing antibodies.

As beave already asked, how much Imuran are you taking?

This might be the confusing part. I'm not sure our GI's know how much Imuran you should take in combination therapy, as opposed to a lone therapy. Many on Imuran alone are taking 100-200mgs per day.

I would agree with beave though, you could always stop the Imuran for a week or so, and see if anything changes.

Regular Member

Date Joined Jan 2006
Total Posts : 80
   Posted 9/18/2017 9:05 AM (GMT -7)   
I am on both Remicade and Imuran. While it has given me a lot of my life back, I am tired a lot. I usually have to take at least a 2 hour nap each day. I retired early at 60 years old because I could not make it through the day. I worked on my feet all day. But to answer your question, I was tired before both the Remicade and Imuran were given together. I have had CD for 25 years and have only been on the 2 for about 3 years.

Regular Member

Date Joined Nov 2015
Total Posts : 273
   Posted 9/18/2017 4:38 PM (GMT -7)   
I take Remicade but not Imuran. What dosage of Imuran are you on? Perhaps you could step down the dosage and see if that helps - meet your doctor in the middle so to speak.
28 year old female
Issues began in July 2014
Capsule endoscopy in late March 2017 showed "suspected Crohn's Ileocolitis"
After colonoscopy on April 14, 2017, was officially diagnosed with Ulcerative Pancolitis (w/ backwash ileitis)
Current meds: Apriso 4 x daily, Prednisone 30 mg, Canasa 1000mg suppository nightly, B12 injections monthly, 50,000 IU Vit D weekly
Started Remicade July 11, 2017

Forum Moderator

Date Joined Aug 2012
Total Posts : 11047
   Posted 9/19/2017 5:56 AM (GMT -7)   
I've heard some say fatigue is associated with Imuran. It might be more of an initial symptom than a sustained symptoms for some. You could try waiting a few months and see if the fatigue goes away.

Maybe suggest replacing Imuran with Methotrexate if it persists?
Moderator Ulcerative Colitis
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Must've been a barking-spider!

New Member

Date Joined Sep 2017
Total Posts : 1
   Posted 9/19/2017 1:06 PM (GMT -7)   
I have been on Imuran for at least ten years, maybe even 15. I never associated it with fatigue, even when they had me on Remicade as well. Have you had your blood work done lately? Maybe your lacking iron or another vitamin or mineral?

New Member

Date Joined Jul 2011
Total Posts : 14
   Posted 9/20/2017 8:10 AM (GMT -7)   
Following this as I just added Imuran to my treatment plan as of yesterday. Currently on Humira but switching to Stelara...anyone on that combo?

We're starting me at a lower dose of Imuran to assess any potential side effects and I have to have blood work done about 10 days in before increasing to my (expected) therapeutic dose (100mg).
Diagnosed with Crohn's: 2002
Past Meds: Pentasa, Remicade, Cimzia, Asacol, Cipro, Flagyl, Lialda, VSL#3
Current Meds: Humira (80mg/week)

Surgeries: Fistulotomies & Seton Placements/Adjustments (September 2011, January 2013 & August 2013); Advancement Flap (December 2013); Temporary Loop Ileostomy (July 2016); Fistula Repair with Gracilis Muscle (September 2016); Fistula Repair (December 2016)

Forum Moderator

Date Joined Feb 2003
Total Posts : 15331
   Posted 9/20/2017 10:02 AM (GMT -7)   
Back many years ago when on Remicade my dr added Imuran to the mix. He said it gave the Remicade a little boost. When I had to switch to Humira he continued the Imuran. I have been on it many, many years with no issues.
Moderator in Chronic Pain & Psoriasis Forums
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