Aziathioprine and Predisolone

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jramg88
New Member


Date Joined Nov 2017
Total Posts : 1
   Posted 11/7/2017 7:44 AM (GMT -7)   
Hi Everyone,

Was diagnosed back in September this year with Crohn's disease, (moderate, pan - colitis, entire colon) and was started on 5-Asa's that day. They had zero effect and three days later I was having the worst flair up I have had yet. After a week of this I seen my gastro nurse and was started on prednisolone aswell, 8 week course starting at 40mg tapering down 5mg every week. I felt great for first few weeks, improved mood energy no crohns symptoms, only negative was the really bad acne that started week3 and is getting worse and worse.
Then two weeks after meeting gastro nurse again she started me on azathioprine starting at 50 mg for week one 100mg for week two, I'm due to go up to 150mg tomorrow and that will be my maintenance dose along with the 5- ASA's. In the last week however my mouth has exploded with mouth ulcers and I've gotten what I think is a urinary tract infection, (painful to pee). My mood was gotten very low also compared to how great I was feeling in the past weeks. Has anyone had any experience of this when they increased dose of azathioprine? Is it more steriod side effects, a combination of the steriods and azathioprime or increasing the azathioprine.
Would be great to hear from anyone who's had similar issues, this is all very knew to me, trying to figure out what medication will work best.

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 3294
   Posted 11/7/2017 8:43 AM (GMT -7)   
It sounds to me like the azathioprine isn't working at all. It sounds like what I had. I was on a ton of 5-ASAs, plus Imuran, plus steroids and I STILL got an abscess and fistula with tons of flares. Switching to Remicade fixed all of that.
"For this thing I besought the Lord thrice that it depart from me. He said, My grace is sufficient for thee: for my strength is made perfect in weakness. Most gladly therefore will I rather glory in my infirmities; I take pleasure in infirmities, reproaches, necessities, persecutions, distresses, for when I am weak, then am I strong" 2 Cor
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