Does this virus play a role in refractory IBD?

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Uniform Charlie
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Date Joined Jul 2015
Total Posts : 550
   Posted 1/3/2018 6:19 AM (GMT -7)   
This article is not brand new, but I don't recall seeing it. Researchers may have found a virus that plays a role in refractory IBD.



Identification of clinically relevant cytomegalovirus infections in patients with inflammatory bowel disease.

"Several lines of evidence indicate that cytomegalovirus infection can be substantially associated with onset of inflammatory bowel disease, especially in patients refractory to immunosuppressive treatment. As cytomegalovirus is widely spread in the population, here we present a quantitative detection system suitable to differentiate clinically relevant cytomegalovirus infection from common latent cytomegalovirus. Using a quantitative real-time PCR approach, cytomegalovirus viral load was evaluated in 917 formalin-fixed and paraffin-embedded colon biopsy samples of 136 patients diagnosed with inflammatory bowel disease. Besides initial cytomegalovirus testing, the PCR system was also used to monitor therapy response after antiviral treatment. Cytomegalovirus DNA was detected in 37 patients (27%) with varying viral loads ranging from 5 to 8.7 × 105 copies/105 cells. Thereof, 13 patients (35%) received an antiviral treatment with 12 of them going into remission (92%). Later, five patients displayed a relapse and three patients who agreed to restart antiviral treatment again showed positive therapy response."

/www.nature.com/articles/modpathol2017149
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