@scifigal - It's very long but the discussion in the thread is fascinating. I'm not sure if I agree with kiny or not, but he is right that Remicade in the beginning was only used as an acute treatment or rescue med, i.e. an infusion as a last resort before surgery. Would be interesting to see the data for those early Remicade users if there's any. I find it hard to believe that just one dose of Remicade would be sufficient for most patients. I have heard of some patients seeing a drastic improvement after one dose, but most patients take more like 2-3 doses, or even longer, to reach remission.
But yeah, kiny's theory about
Remicade blocking the innate immune response and triggering the adaptive immune system to keep on attacking does make sense in the context of the article and Remicade stopping working after a time for so many people. There are numerous inflammation pathways in the body; and if one is blocked, the body finds new pathways with which to trigger inflammation and cause you misery.
However, I don't agree with his conclusions that we should just all stop taking Remicade after one dose and suck it up. (I'm sorry: enteral nutrition is not
a viable long-term solution. Besides, even he admits it doesn't work very well for colitis.)
What we need is a radical breakthrough in Crohn's treatments. Desperately. It won't be MAP antibiotics or messing about
with the gut flora; the only faint glimmer of hope on the horizon seems to be Qu Biologics :-/
Dx Crohn's in June 2000. (Yay )
Tried: 5-ASAs, azathioprine, 6MP, Remicade, methotrexate, Humira, diets.
1st surgery 20/2/13 - subtotal colectomy with end ileostomy.
2nd surgery 10/7/15 - ileorectal anastomosis. Stoma reversed and ileum connected to the rectum.
Current status: Chronic flare. Do I have any other kind?
Current meds: 50mg 6MP; Entyvio (started 3/11/16)