6-MP or Imuran reactions?

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New Member

Date Joined May 2007
Total Posts : 5
   Posted 8/24/2007 1:25 PM (GMT -7)   
Anyone have 6-MP or Imuran reactions?  My GI said that he'd never had any patients have the same reaction to the two different meds.  I tried the two in the past two months (tried 6-MP 3x - at my Dr's urging and Imuran 1x) - extreme!!!!! abdominal pain.  After taking the meds and lying down - it took around 2 hrs before the pain set in and kinda felt like someone squeezing and stabbing my entire GI tract.  Took about 8 hrs before the pain calmed down enough so I could sit or lie still for longer than 5 min.
10yrs Dx'd w/Crohn's

Veteran Member

Date Joined Mar 2007
Total Posts : 1632
   Posted 8/24/2007 1:38 PM (GMT -7)   
When you say you tried 6-mp three times, do you mean just three doses?  Are you saying two hours after you took it the first time, you had this pain?

It sounds like pancreatitis to me.  That's a possible effect of both Imuran and 6-mp for some people and can happen after just one dose.   
If it happens to you with one of these two meds, it could definitely happen with the other one too.

New Member

Date Joined May 2007
Total Posts : 5
   Posted 8/24/2007 1:51 PM (GMT -7)   
I took one dose of the 6-MP on Wed. evening after I picked up the prescription - terrible pain all night.  I thought that this might be a reaction from a change from Prednisone to Entocort so I went off the Entocort and went back on the Pred.  By the 2nd dose on Thus. my husband wanted to take me to the hospital - didn't go, decided to call GI.  I then called my GI and he said I probably just had a tummy bug (I never wanted to say explicitives so bad in all my life), so I took his advise, waited a few days and took the 6-MP again (same thing).  I called again (my GI's 2hrs away) and set up another appointment.  After, I went on Imuran (got smarter and only took the one dose when it caused the same reaction). 

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 8/24/2007 3:17 PM (GMT -7)   
Hi Magans I never lie down after meds I take my Imuran at supper with food don't know if that makes a difference but yah I would see my GI about that much pain going on and for that long .Have you been having pains or did they just start? Hope your feeling better.lol gail

Regular Member

Date Joined Dec 2006
Total Posts : 244
   Posted 8/24/2007 6:15 PM (GMT -7)   
Hi Magans -

I am currently taking both without any side effects or reactions. I also take my Imuran with dinner and it seems to help. I hopw you feel better soon!

MMAC, Wife & Mother of 3 (14, 13 & 7) - Diagnosed w/CD June05 (terminal ileum)

Asacol (9 daily), Imuran (150mg), Prenisone (15mg), Cipro (1000mg)Lunesta (3mg), Phenergan (when needed) - Remicade as of 7/24

Regular Member

Date Joined Apr 2010
Total Posts : 232
   Posted 6/1/2012 2:12 PM (GMT -7)   
I had a huge reaction to Imuran. And my doctor denied me too. I found out years later, when I was being interviewed for the human genome IBD project, that I was not alone, that was easily 4 years after the fact. (Man, if I had had the internet then...)

My stomach was already killing me, duodenal & small bowel, CD. So even though it killed, I didn't complain about the pain -- too inured to it, and had crappy doctor's who ignored my pain. I did complain about severe fatigue.

After about two weeks my knees started aching and every time I stood up, it felt like I'd lost all the soft tissue in my knees, and it was bone on bone-- breathtaking pain and I became achy all over. I talked to the, ahem, doctor, as I was feeling worse and functioning less.

I rode it out some more.

about a month into it, I could barely get out of my house and I then got a funky fever. I was taking my dose in the morning, by dinner the fever would be up. The interesting part, was that it would break in the very early morning.

The next few days went like this Day 1, 100 Day 2, 101, Day 3, 102... this continued until the day I got up to 107 (I was 29 years old).

I was living alone and got in the habit of walking around with my non-cordless phone. Thank God I did.

I had just started antibiotics on my GI's request. She decided I had the flu.

The last day I took my almost last Imuran, my fever was at 107 by 3 in the afternoon. I went to lay down and was on my stomach. I realized I had forgotten to take the anti B, and tried to get up. Every muscle attached to my spine, from my neck to my tail bone seized at once. I have never, not from broken jaw or Crohn's screamed so loud in my life.

And I had to call someone to come open my apartment door and I called an ambulance, I also passed out for the first time in my life -- after 8 years of CD. I think I held on pretty well!

Still my GI decided that this was not a reaction to Imuran but some bug. I tried it again, 4 months later, at her insistence. My knees went after 3 days. I stopped it. I had all the information I needed. I cried for a week after that. There were no other drugs for me to try and the GI decided that I was not being compliant, yes I eventually fired her.

Sick as I was before that, it took me a year to get out of my home and back to work.

Imuran can be too much for some of us, of this I am certain.
CD 25 years. Multiple surgeries in past 10 yrs. 4 year Illeostomy and looking down the barrel of another (fistulas due to surgery, not CD) . Mesh rejection. Large incisional hernia. Perpetually underweight. Short bowel syndrome. Have used a variety of complementary medical therapies. Highly recommend Bowen Therapy as the best body work. Take me vites. Started Low Dose Naltrexone March 27, 201

Post Edited (MToronto2) : 6/2/2012 12:06:13 AM (GMT-6)

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