I'm not on prednisone now but have been in the past. The night sweats were terrible. My dr confirmed they were a result of p and could offer no help. The sweats got better when I began to reduce my dose as I was getting off the stuff. Soft absorbant tee shirt sheets helped me a little. I would put a towel under me and then remove it when it got wet, with a change of gowns and a new pillow I was again dry and back to sleep for a while.