Problem with Remicade if allergic to animals?

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Regular Member

Date Joined Aug 2007
Total Posts : 89
   Posted 9/5/2007 9:33 AM (GMT -7)   
Do I understand correctly that Remicade is made partly of mouse protein? If that's true, has anyone with animal allergies had trouble taking it? My doc wants to discuss starting Remicade but I know I am mildly allergic to cats, dogs, horses (although I live with 2 cats and a poodle dog!)
Dx'd CD in August 2007
Allergic to Entocort and Prednisone / Not sure what's next
Currently on Protonix

Veteran Member

Date Joined Sep 2006
Total Posts : 2527
   Posted 9/5/2007 11:13 AM (GMT -7)   
I am allergic to acts and dogs and got remicade. Yes there is maouse proyein or something in it. I worked at an animal hospital with my allergies and have pets of my own. They premed with benadryl and tylenol unless they use claratin (1 place I went used that 1st then benadryl if needed. There is a nurse on hand for any reactions tell them right away if you are itchy or feel funny
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 9/5/2007 12:36 PM (GMT -7)   
Hi yes Remicade is made with mouse protein. I have been on it for over 2 years and doing fine.
The only side effect is I have a craving for cheese afterwards. LOL
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007

Regular Member

Date Joined Jun 2007
Total Posts : 340
   Posted 9/5/2007 1:09 PM (GMT -7)   
I have TONS of allergies. Many animal, some food, medications... I had an allergic reaction to my first and 2nd infusion so far (third scheduled soon) and they just stopped the infusion, administered more benedryl and then restarted the infusion at a slower rate. This was with me being premedicated with tylenol, hydrocortisone, and benedryl... but they had it under control.

you should be fine! if you have a reaction, they will take care of it, just make sure you tell them if you have trouble breathing, are itchy, shaky, sweaty or just don't feel right.
Finally Dx- April 13 2007 (age 26) ilio-crohn's-colitis. Surgeries:appendectomy, cholecystectomy, tonsillectomy, pinidal cyst removed,emergency abdominal surgery for hemorrhaging ovary from burst ovarian cyst, LEEPcervix, emergency abdominal surgery for grapefruit sized ovarian cyst removal, D and C of uterus, lumpectomy of breast.
MEDS: remicade, prednisone, Asacol TID, protonix, metformin, buspar, trazodone, multi V, B complex, flaxseed. Vegetarian, leaning towards vegan. no nuts, seeds, or wheat.
Many allergies. Polycystic ovarian syndrome, anxiety, depression, ITP 
Every tool is a weapon if you hold it right ~ Ani Difranco

Veteran Member

Date Joined Nov 2005
Total Posts : 722
   Posted 9/5/2007 1:18 PM (GMT -7)   
I was under the impression that remicade was made out of a substance that mimics mouse protein but is not actually mouse protein. Maybe I am incorrect but I heard this from my remicade nurse.....Don't flame me here! :-) Just repeating what I was told.
36 year old female. Dx'd and undx'd a few times. Was just redx'd again 04/2007.
History of rectal abscesses and fistulas (28 surgeries including abscess I & D, exploratory surgeries, 2 C-ton drains and 1 fistula plug) Count does not include self bursting abscesses.
1st Remicade infusion 6/5/07.  Lots of joint pain, and a new fistula since the 2nd infusion 6/19.
Praying I'll get better soon so we can have a baby.
Ginger :)

gemini kiwi
Veteran Member

Date Joined Nov 2006
Total Posts : 1136
   Posted 9/5/2007 1:52 PM (GMT -7)   
This is a question I've been meaning to ask. Call me thick ..................but why is it when we have a reaction to some anti-biotics and or other types of medication etc it gets noted on your records, some get to wear a medic alert bracelet, and it is indeed a life threatening situation if you are ever administered it again and yet people break out in hives have trouble breathing loads of other alergic reactions and they dose you up with tylenol or benadryl and continue administering Remicade.

Just wondering.

Veteran Member

Date Joined Oct 2006
Total Posts : 2082
   Posted 9/5/2007 6:25 PM (GMT -7)   
I had the same question since I was bitten by a mouse as a child and worried that I'd built up antibodies. My rheumatologist told me in my case that there would not have been enough mouse protein on the teeth of said offending mouse for me to build up any antibodies.
48 yr. old. Ileocolitis.  CD since early teens, misdx'd until age 36.  Hemicolectomy-left side in 2001.  Disease returned in 2003. Arthritis, episcleritis, chronic pain due to surgeries (nerve damage, adhesions) and disease.  Recently dx'd scoliosis.  History of endometriosis.

Veteran Member

Date Joined Feb 2006
Total Posts : 842
   Posted 9/5/2007 7:17 PM (GMT -7)   
I know in the Remicade patient information, it does state that if you are allergic to mice, you shouldn't take Remicade, but nothing about other animals.
Crohn's Disease for a year and counting
Imuran: 150mg
Remicade: Had a delayed reaction, waiting for Humira approval
Dicyclomine and hyoscamine for intestinal cramping and spasms <--This link will be changing, but for now it works!

Forum Moderator

Date Joined Nov 2003
Total Posts : 7122
   Posted 9/5/2007 7:56 PM (GMT -7)   
Remicade is made up of about 75% human antibody and 25% mouse antibody. The Remicade literature states that you should not take it if allergic to mouse PROTEIN, not mice. Allergy to dogs or cats, farm animals, or humans should not prevent you from receiving Remicade.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?

New Member

Date Joined Jul 2007
Total Posts : 5
   Posted 9/5/2007 8:14 PM (GMT -7)   
I am extremely allergic to any animal with any fur and have taken Remicade for seven years since it first came out and never had a problem!  I'm not currently taking it because it's starting to not work so well because I'm building up antibodies to it.  I'm trying Humira but's it's not working nearly as well!  Anyway, no worries, but I hope it does for you what it did for me.  It really gave me my life back and I never had any problems. Good luck!

Crohn's for 13 years. Curently taking Methotrexate, Humira, Xifaxan, and Colazal with all intestines still intact.  

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