Is there a test to predict if we have the gene for colon cancer

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Regular Member

Date Joined Sep 2007
Total Posts : 219
   Posted 9/6/2007 3:27 PM (GMT -7)   
Hi all
Went for my second opinion on my newly diagnosed crohn's disease and was given the choice of top down approach and bottom up.  Either way I was driving home and thought is there a test to predict if a person has a genetic disposition for colon cancer.  REason being that the gi doc said there has been some case reports of lymphoma following remicade treatment. I told the doc my daughter had leukemia a few years ago and since they are both blood cancers she said I should discuss it and think about everything.  I have been on the pentasa and endocort for a week and my sharp colon pain is gone so that is good now to get rid of the diarrhea would be great!! 
Hopefully someone knows this answer.

Veteran Member

Date Joined Mar 2006
Total Posts : 1169
   Posted 9/7/2007 6:00 AM (GMT -7)   
There is a genetic connection in some forms of colon cancer, though I believe a better indicator is if you ahve had any first-degree relatives develop colon cancer at early ages. However, lymphoma and leukemia are different from colon cancer and probably do not have the same genetic setups, if any. I do know that lymphoma can run in families, though again I suspect thre medical histories are better indicators than genes. Most of the research I have seen shows very, very small probabilities of any cancers related to the primary Crohn's treatments. However, where such numbers exist, they mostly relate tothe top-doen treatments, not the bottom-ups. And of course an identified factor in the development of lymphoma in Crohn's patients, as well as colon cancer, is uncontrolled long term inflammation from the disease itself. So treat and run a tiny risk or don't treat, be less comfortable and also run a small but identifiable risk. Hard call. Most patients opt for better quality of life through treatment.

Regular Member

Date Joined Sep 2007
Total Posts : 219
   Posted 9/7/2007 2:43 PM (GMT -7)   
Thanks Mike.  That makes sense!!! Now I have to decide top down or bottom up.  I definitely am staying the course on the pentasa and entocort as my pain is subsiding so it must be working.  I am going for one more opinion and then I will decide for sure. 
Have a good nite!
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