NOD2/ Card 15 Genetic Testing

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Sep 2007
Total Posts : 219
   Posted 9/12/2007 4:59 PM (GMT -7)   
I am newly diagnosed and have been posting for the last 2 weeks since diagnoses.  I have tried to read anything I can to learn about my disease to be educated and make good decisions about my treatment.  I recently learned about the genetic testing for NOD2/Card 15.  The presence of these markers "could" indicate a more aggressive disease in crohn's patients.  I know that this is all research at this point and they do not know if this exactly correlates with outcome.  I am very interested in finding out if I have this marker and was wondering if anyone else had this testing.
Also the Prometheus testing Anti-CBir 1 test on mine came out 31.1 and the reference value is <21. and this is suppose to be corelated with small bowel fibrostenosing and internal penetrating disease. 
So now I am scared about all this and am very interested in getting further markers tested. 
Maybe I should choose the remicade based on all this...just afraid of all the side effects.  I don't have good luck anyway. 

Regular Member

Date Joined Aug 2005
Total Posts : 244
   Posted 9/12/2007 6:49 PM (GMT -7)   
i do not know about my marker status but my chrons/colitis was helped by remicade. i still worry about anti-bodies, this drug seems to lose effectiveness in me. my doc wants me to wait until the remicade is out of steam then i can switch to humira.
"If thou wilt be observant and vigilant, thou wilt see at every moment the response to thy action. Be observant if thou wouldst have a pure heart, for something is born to thee in consequence of every action." -Rumi-
CD for 15 years diagnosed at age 11(i get the crohns cycle)

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 9/12/2007 6:57 PM (GMT -7)   
Have not had any genetic testing done but let me offer a word of caution in this area. Even though you may want to have this done to have a better understanding of this disease and how it is going to affect you......genetic testing NOT paid for out of pocket, i.e.; getting your doctor to order it and the insurance company to pay for it is NOT a good idea. It gives your insurance company way tooo much information on you and could backfire on your future insurance claims. They are always looking for pre-existing medical reasons not to pay a claim and God forbid you get in the situtation of losing your insurance, seeking out another insurance company and they have THAT kind of information in their pockets! Proceed with caution.

I did Remicade for over a year with much success until building antibodies to it. Would recommend you keep some Benedryl on hand for infusion days just in case you have a reaction. Also, try and schedule you infusion days on Fridays so if you have flu like side effects for a couple of days, you'll have the weekend for down time. I have recently changed to Humira and so far so good. Good luck to you with your decisions and as always welcome to the board!
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Remicade, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain.  Lactose Intolerant?
Attitude: When I stand before G-D at the end of my life, I want to be able to say; I used every talent you gave me in a positive way to help others along their way!

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 9/12/2007 7:39 PM (GMT -7)   
Hi Nikki Haven't had all that done but am on Rem. You should not let yourself get too scarred about this I sort of just take it a day or month at a time .Your GI DR. should know how to treat you best and what has he suggested for treatment? CD was a scarry thing for me at first but now I can handle it better .You certainly did some homework I never thought of getting those test done yet. Thanks for mentioning gail
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, December 11, 2017 2:49 AM (GMT -7)
There are a total of 2,903,886 posts in 318,695 threads.
View Active Threads

Who's Online
This forum has 158106 registered members. Please welcome our newest member, Pottybutt.
220 Guest(s), 3 Registered Member(s) are currently online.  Details
Turboz, jmadrid, testuser1234