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Antidepressant/Migraine Drugs Don't Mix!

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Crohn's Disease
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broomhilda
Veteran Member
Joined : May 2007
Posts : 1495
Posted 9/12/2007 6:40 PM (GMT -8)
God, this disease is making me develop a fined tuned "alarmist" attitude!  However, I did my homework on this one and didn't like what I found.  You make the call.

There are a host of migraine drugs,i.e.; Imitrex, Maxalt, etc. that do not mix with antidepressants such as Zoloft, Prozac, etc.  Seems the mix falls into a catagory of "Class 2- Severe Interaction" definition.

Most migraine drugs carry heavy warnings for anyone with heart/BP related problems but the problem comes with the possiblity of mixing the antidepressant drugs and the risk of Serotonin Syndrome.  Serotonin Syndrome may result in death as well.  My pharmacist/boss was scared of the mix too.  He is a migraine sufferer as well.

Some patients have experienced Serotonin Syndrome within 10 minutes to an hour of mixing the two types of drugs. 

Please Google info on the Serotonin Syndrome if you take meds for migraines and antidepressants.  Too much info to post.

My question came in with an Rx for Imitrex and Lexapro which I already take.  For me, I'm not touching the Imitrex with a 10 ft. pole!  I have several types of different migraines, some drug related some not.  Today, I had a sinus migraine and took my percocet and slept it off for 4 hours.

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Howlyncat
Elite Member
Joined : Jan 2005
Posts : 24909
Posted 9/13/2007 6:28 AM (GMT -8)
Thanks for the heads up ...............
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immunosci
Regular Member
Joined : Jun 2006
Posts : 326
Posted 9/13/2007 7:15 AM (GMT -8)
I ran into the same problem when I was switched to Cymbalta for depression. I couldn't take Axert any more for migraines. I've ended up doing what you did - percocet and sleep!

Jen
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dragonfly137927
Veteran Member
Joined : Sep 2006
Posts : 2527
Posted 9/13/2007 7:38 AM (GMT -8)
I actually take amitryptaline (sp?) to prevent migraines and that was initially prescribed for depression. When I get a migraine I take relpax, both imitrex and maxalt didnt help me.
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