Antidepressant/Migraine Drugs Don't Mix!

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Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 9/12/2007 7:40 PM (GMT -7)   
God, this disease is making me develop a fined tuned "alarmist" attitude!  However, I did my homework on this one and didn't like what I found.  You make the call.
There are a host of migraine drugs,i.e.; Imitrex, Maxalt, etc. that do not mix with antidepressants such as Zoloft, Prozac, etc.  Seems the mix falls into a catagory of "Class 2- Severe Interaction" definition.
Most migraine drugs carry heavy warnings for anyone with heart/BP related problems but the problem comes with the possiblity of mixing the antidepressant drugs and the risk of Serotonin Syndrome.  Serotonin Syndrome may result in death as well.  My pharmacist/boss was scared of the mix too.  He is a migraine sufferer as well.
Some patients have experienced Serotonin Syndrome within 10 minutes to an hour of mixing the two types of drugs. 
Please Google info on the Serotonin Syndrome if you take meds for migraines and antidepressants.  Too much info to post.
My question came in with an Rx for Imitrex and Lexapro which I already take.  For me, I'm not touching the Imitrex with a 10 ft. pole!  I have several types of different migraines, some drug related some not.  Today, I had a sinus migraine and took my percocet and slept it off for 4 hours.
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Remicade, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain.  Lactose Intolerant?
Attitude: When I stand before G-D at the end of my life, I want to be able to say; I used every talent you gave me in a positive way to help others along their way!

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Date Joined Jan 2005
Total Posts : 24909
   Posted 9/13/2007 7:28 AM (GMT -7)   
Thanks for the heads up ...............
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Regular Member

Date Joined Jun 2006
Total Posts : 326
   Posted 9/13/2007 8:15 AM (GMT -7)   
I ran into the same problem when I was switched to Cymbalta for depression. I couldn't take Axert any more for migraines. I've ended up doing what you did - percocet and sleep!

-Formal diagnosis of Crohn's Disease in ileum in July 2005.
-Experienced what were most likely flares for 12-15 ys.
-6-MP, protonix, cymbalta, wellbutrin, trazadone, miralax, allegra

Veteran Member

Date Joined Sep 2006
Total Posts : 2527
   Posted 9/13/2007 8:38 AM (GMT -7)   
I actually take amitryptaline (sp?) to prevent migraines and that was initially prescribed for depression. When I get a migraine I take relpax, both imitrex and maxalt didnt help me.
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987

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