I have some questions about prednisone withdrawal, and hope someone can help me. My 78 year old mother has been on and off prednisone for about 8 years for emphysema. This past year she had a lung abcess on top of her COPD. Doctor had her on 40 mg in hospital and reduced her to 20 mg when he released her last Sunday. He also had her on two antibiotics, which he cold turkeyed on Saturday because she was doing so well. On Monday we found ourselves in the ER. She was unable to get out of bed on Monday morning and her blood pressure was 183/70. My mother NEVER had high blood pressure before. Went to doctor on Tuesday. Put her back on Levaquin, and she improved somewhat. Put her back on prednisone on Friday (40 mg - 4 days, 30 mg - 3 days, 20 mg - 3 days, 10 mg - 3 days) to try to get her back to where she was when she got out of hosptal. Well, it worked. She was great Thursday and Friday - but Saturday and Sunday she was shakey and weak with a "fuzzy head." Also complained of cramps in her legs. She had just finished taking the 30 mg and was starting 20 when this happened. I have been reading other posts about prednisone withdraw, and I think that the blood pressure spike and her shaking, weakness and fuzzy head have been caused by her going off prednisone. I have told her what I have read, and she is thinking of going back on 30 mg for a few days then cutting down to 25 mg, 20mg, etc until she gets to 10. Any comments or ideas would be really appreciated. Thank you.