I started Humira a week and a half ago. I went from having D several times a day for years, to being constipated today. Hoping it will even itself out, lol.
I use the pens and did all four shots in the tummy. I think I will try the thighs for my next dose, because we're supposed to rotate.
For your original question, I'll put it this way... it certainly doesn't feel good!