Never did the syringe for Humira...and have only done 8 pens....4,2,2...the first 6 in the stomach and the last 2 in thighs. yes it hurts once the medicine goes in....but I am guessing that it would burn no matter how it is injected.
The pen causes the needle to go in so quick that I don't ever really feel the injection itself...and the burn passes after a minute or two.....I will stick with the pen since I have to inject myself sometimes...tonight was the first time...and it went fine.
I've never tried the syringes, but the Humira pens are really painful. I can't imagine the syringes would be better. With or without ice, I can't stick the pen into my stomach - there's been too much pain there from previous surgeries, so the pen goes into my thigh. Then I put ice on afterward to prevent the redness from the injection site. Can't really tell if the Humira is working - guess if I don't go into the hospital with an inflammation, it will be a success. I'm also still taking Imuran and Pentasa - was also on Entecort but am trying to wean off because of constant migraines.