6mp works very well for me and for many on this board. The main problems are that it takes some time -- as long as 3-6 months -- to work up to full effectiveness, and that with a few patients it depresses white cells. As for remicade, at least as many, if not more, seem to have pretty annoying allergic reactions. One course might be a low does of prednisone while starting 6mp and then drop the pred as it kicks in. Of course every case is unique . . . but in my view, it doesn't make sense to go with the biggest gun until you know for sure that the decent-caliber one (6mP) isn't going to work.