6mp vs. Remicade

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Regular Member

Date Joined Aug 2004
Total Posts : 24
   Posted 10/9/2007 3:49 AM (GMT -7)   
My crohns is very active after having been mostly quiet for a few years.  These two meds are my options. My doctor is recommending remicade as it works faster/stronger.  The side effects of remicade unnerve me, especially the lymphoma...also the rough weaning process of remicade makes me nervous as well.
Any thoughts on either of the two meds?

Veteran Member

Date Joined Mar 2006
Total Posts : 1169
   Posted 10/9/2007 5:34 AM (GMT -7)   
6mp works very well for me and for many on this board. The main problems are that it takes some time -- as long as 3-6 months -- to work up to full effectiveness, and that with a few patients it depresses white cells. As for remicade, at least as many, if not more, seem to have pretty annoying allergic reactions. One course might be a low does of prednisone while starting 6mp and then drop the pred as it kicks in. Of course every case is unique . . . but in my view, it doesn't make sense to go with the biggest gun until you know for sure that the decent-caliber one (6mP) isn't going to work.

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 10/9/2007 5:48 AM (GMT -7)   
What weaning process are you talking about with remicade?

I have been on imuran and remicade for almost 3 years. Imuran/6mp usually needs something else along with it to get you into remission, but it has a great track record for keeping you in remission once you get there. I have had no side effects with remicade. With imuran, I severe nausea, and fatigue, but once I started taking it at night, that resolved. I also had quite a bit of hair loss with imuran for about a period of a month, and then it stopped, and it all grew back.

Regular Member

Date Joined Aug 2004
Total Posts : 24
   Posted 10/9/2007 6:14 AM (GMT -7)   
If it helps any...I am taking asacol and entocort as well.

Maybe I need to make a sig with all my details. :)

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 10/9/2007 6:14 AM (GMT -7)   
Hi, I also am on Remicade and Imuran for over2 years now and I am enjoyng the remission from both
these drugs. I have read alot about Remicade from the website. I made the right choice with Remicade.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007

Veteran Member

Date Joined Mar 2006
Total Posts : 1034
   Posted 10/9/2007 7:41 PM (GMT -7)   
i have been on 6-mp since 1995. i have always questioned its efficacy since i never felt any better and got on it to get off prednisone but that never happened by taking 6-mp. it wasnt until about 5 years later with the release of remicade that i was able to do that. now i am having anemia problems and have had to get 2 transfusions in as many months. 6-mp causes bone marrow suppression and i highly suspect that this is a long term side effect i am now experiencing. i did some research on 6-mp and it is a scary drug. i need to talk to my doc to get off of it. i never felt it worked for me and i want to see if getting off it fixes my anemia problem (the hematologist just wants me to pay him to monitor my blood and not do anything - thanks for nothing). as for remicade, from hindsight in my personal experience, i dont think this medicine works. yes, i felt tons better when taking it, which i did for years. i was getting it every other month for years. i even got double doses at times. i felt stronger and had more energy after receiving an infusion and symptoms would subside, although not wholly go away (still had abdominal pains, although not as major, still had a problem with D and had to do bathroom mapping). in july 2005 i had surgery to remove 8 inches of my sigmoid colon. the disease had progressed and gotten worse and i had developed a fistula from my colon to my bladder. one of the things remicade is supposed to treat and prevent are fistulas. so you can see why i no longer feel this medicine did what it promised. i havent taken it since december of 2006 and i dont plan to take it ever again. oh, and be aware that this is a short term drug. it is matter of time before your body builds up antibodies to it and it does not become as effective as it used to and thus you'll need to find a different drug to take.

from my personal experience, i feel that 6-mp is useless (unless you want to get leukemia or lymphoma - do the research and you'll see) and remicade just masks the symptoms - making you feel better but does not treat or cure the disease. so my advice on these 2 medications is to find something else. i know i am in the great minority here, but divergent viewpoints can be good to hear. and for those who think that these medications are helping and those who know that they are, then stick with it. perhaps it can actually do something for some one.

sorry for the cynicism on this.
Crazy Harry

Crohn's since 1993 (17 yrs old then)
been on basically every med available, currently on colozal & 6-mp
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon

Regular Member

Date Joined Sep 2007
Total Posts : 330
   Posted 10/9/2007 8:03 PM (GMT -7)   
I have the same question you do. My doctor has suggested that my "next step" might be Remicade, but from web research, books etc it seems as if 6 mp would be the logical step. (I'm on Pentasa, Pred and Cipro now.) I was wondering if there's a change in the protocol to skip over 6 mp and go with the Remicade? I don't love either choice, frankly. I'm meeting with him on Monday to discuss. Let us know what you decide!

(For the record, my GI shared with me that he feels that as we learn more about Remicade from years of use, he is less and less convinced that it's as wonderful as everyone hoped it would be. Yet, he's still suggesting it!)
44 years old, newly diagnosed after an 8-day hospitalization in September 2007 but symptoms for several years before that.
Taking Pentasa, Prednisone (tapering), Cipro, Prilosec, probiotics, calcium and a multi-vitamin -- also Levoxyl for hypothyroid (Dx 2004)
Gall bladder surgery in 1997.
Single working mom to three wonderful kids, ages 9 to 15.

So appreciative to have this forum -- it's all new to me!

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