Remicade and Large Weight Gain Confirmed - 60 - 75 POUNDS! - Have you gained weight?

Have you gained weight with Remicade?
YES - OVER 25 POUNDS - 30.2%
YES - UNDER 25 POUNDS - 30.2%

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Regular Member

Date Joined Mar 2005
Total Posts : 31
   Posted 10/15/2007 10:08 PM (GMT -7)   
Wow Very interesting study! At least now I'll have an excuse.... what's everyone think? Have you gained weight?

Fascinating article! Thanks.

I edited out the article itself, because it's very long and uses a lot of expensive server space to store and reproduce. If we're to keep this site free, we need to be as economical with server space as we can.

Please just provide a link in the future... but wow! what a great link it is. Thanks very much - Ivy.

Post Edited By Moderator (ivy6) : 12/8/2009 5:20:29 PM (GMT-7)

Mormor Vicky
Veteran Member

Date Joined Mar 2007
Total Posts : 684
   Posted 10/16/2007 5:27 AM (GMT -7)   
I can't vote because I've never been on remicade, but I believe I've developed a new fistula and I'm afraid I'll be put on it.  I've struggled for the last year to lose 60 and I have 40 more.  Now I don't know what to do.
Vicky / 47 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
Daughter (26) also has Crohn's since she was 12.
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor

potty pooper
Regular Member

Date Joined Dec 2006
Total Posts : 375
   Posted 10/16/2007 7:15 AM (GMT -7)   
Wow, that's interesting. I've had 7 infusions to date. I haven't notice any weight gain as yet, but I had put on some weight before I started. I've struggled with being too skinny my whole life and being able to put on some weight (although not 60-75 lbs!) would be welcome. I'm pretty happy with my weight right now - except I wish I could move it to some more desirable places!

Maybe the positive reaction to remicade that many patients get results in better absorption, which leads to weight gain.

Thanks for the info.

Regular Member

Date Joined Nov 2005
Total Posts : 77
   Posted 10/16/2007 8:29 PM (GMT -7)   

Very interesting.  My 9 year old son has been on Remicade for 2 years now.  He started out at 60 lbs and as of lasts week treatment he is 106lbs.  I asked his GI about Remicade and weight gain at his last visit and he said it wasn't from the Remicade.  My son is very active, playing tackle football right now.  Practices 3xs a week with games on Saturday.  Outside playing all day when not in school.  I will definately bring this up at his next treatment.


Sam 9 CD

Regular Member

Date Joined Apr 2007
Total Posts : 345
   Posted 10/17/2007 6:47 AM (GMT -7)   
I just think it is simply because we are better. No scientific study needed. We feel better, so we eat. Most who need radical treatment are very underweight. I know I was.
32 years old. Diagnosed in 2002ish. 
Taking Asacol, Lomotil TID, and on Remicade since 2004. 
Lower Bowel area only, except for the short stint (about 2 weeks) that I had mouth sores.  Also have external/anal fistula and anal/vaginal fistula. 

Veteran Member

Date Joined Dec 2006
Total Posts : 1986
   Posted 10/17/2007 6:53 AM (GMT -7)   
Well at least now I have an excuse for the weight I've gained.
49 years old, CD since I was a child.    
Six resection surgeries, permanent ostomy, adverse reactions to Remicade finally off of Prednisone, back on 6MP for maintenance, hoping for a long remission from this last surgery. 

Regular Member

Date Joined Feb 2004
Total Posts : 65
   Posted 10/17/2007 7:48 AM (GMT -7)   
I have been on remicade for 3 + years and I have lost 30+ pounds the last  3-4 months and no one can explain. I also have GERD real bad...had part of my insides taken out...doctors dont seem to care, I cannot wear my watch or wedding ring. My pants size is down 4 sizes, I wasnt even a 32 in Jr do not no why ....


Regular Member

Date Joined Oct 2007
Total Posts : 76
   Posted 10/17/2007 12:09 PM (GMT -7)   
Wow, very interesting....I gained some weight when I first started Remicade, then went off of it during my pregnancy. I lost all the baby weight within a few weeks of giving birth, but then gained it all back plus some, and I could not figure out why for the life of me....I guess Remicade could have been the reason! Thankfully I've now lost 63 pounds in the last 9 months, not so thankfully though, because I've been so sick!

Asthma (diagnosed at 12)
Fibromyalgia (diagnosed 9/01)
Crohn's Disease/Colitis (diagnosed 12/02)
Diverticulitis (diagnosed 6/07)
Chronic pelvic pain/endometriosis, leading to hysterectomy (9/07)
Torn rotator cuff/labrum (repair 11/20/07)
Bladder sling (8/06), cholystectomy (2/06), tubal ligation (2/06), failed ablation (3/07)
Taking Lialda, Prednisone, Entocort, Remicade, Bentyl, NuLev, HCTZ, Lisinopril, Cymbalta, Effexor, Xifaxan, Flagyl, Lomotil, Frova, Questran powder/Carafate suspension, and pain meds.

New Member

Date Joined Oct 2007
Total Posts : 8
   Posted 10/17/2007 1:44 PM (GMT -7)   
I've been on Remicade since 2002. I've definitely gained more than 25 lbs., but I was down 40 lbs. before doctors decided to try Remicade. The last few years, my weight has been up and now but not to the extremes. I'm not sure how I feel about this report, but I'll latch on to any excuse for weight gain...
Age: 37
Diagnosed in 1987; Flare-ups in 1987, 1994, 2001
Surgeries in 1987 and 1994
Current meds: 6MP, Prevacid, Remicade (every 8 wks)

Regular Member

Date Joined Aug 2006
Total Posts : 177
   Posted 10/17/2007 3:46 PM (GMT -7)   
i've been on it for 11 months and haven't gained any. but having lost any either.
38 yrs old male. dx with cd of ileum June 2006.
3 feet of large intestine and 1 1/2 feet of small intestine removed because of complications from diverticulitis (fall '03) i.e. hartman's surgery(starting to wonder if i was misdiagonized and was actually CD)
med. : 100mg imuran ,remicade Dec.06 every 6 weeks
 arthritis in fingers and knees

Forum Moderator

Date Joined Nov 2003
Total Posts : 7119
   Posted 10/17/2007 4:01 PM (GMT -7)   
Almost three years on Remicade [27 infusions] and I LOST 43 pounds during that time. No one could explain the weight noss. I was eating a better, more balanced diet than prior to Remicade because my gut went into remission after the 3rd infusion.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?

Regular Member

Date Joined May 2007
Total Posts : 148
   Posted 10/17/2007 6:04 PM (GMT -7)   
Interesting. I just switched over to HUMIRA and have started gaining weight. I am also constantly hungry!

Aimee =)
Veteran Member

Date Joined Jun 2004
Total Posts : 1020
   Posted 10/17/2007 8:55 PM (GMT -7)   
I gained a ton of weight, but I honestly think it was because I felt so much better so I ate anything I wanted! =)

But heck, I'll blame it on the medication. I'm on Humira now and am trying to keep the weight that I lost while sick off.

Regular Member

Date Joined Sep 2007
Total Posts : 330
   Posted 10/18/2007 8:21 PM (GMT -7)   
This worries me. I am already about 40 pounds overweight and can't afford to gain more!
44 years old, newly diagnosed after an 8-day hospitalization in September 2007 but symptoms for several years before that.
Medications: Pentasa, Prednisone (tapering), Cipro, Prilosec.
Supplements: probiotics, calcium, vitamin C, vitamin E and a multi-vitamin.
History of hypothyroid (dx 2004, taking Synthroid) and gall bladder surgery (1997).
Single working mom to three wonderful kids, ages 9 to 15.

Regular Member

Date Joined Oct 2007
Total Posts : 31
   Posted 10/18/2007 10:20 PM (GMT -7)   
I hope not. I am going to start Remicade soon. I'm already overweight. Oh I hope not!
37 year old female diagnosed with CD 1 1/2 years ago. On Pentasa, Entocort EC, Prilosec, Promethazine, Vicodin, Ativan and Zoloft.

New Member

Date Joined Sep 2007
Total Posts : 2
   Posted 11/2/2007 5:58 PM (GMT -7)   
I was on remicade for 12 months. Gained about 10 pound that year. When I was forced to go on Humira, well, been on it for 6 months and have gained 20 pounds. Doc checked my diet and exercise..all OK. No reason for gain. I say Humira. Never got an infection on remicade, but now have one on Humira. Miss remicade.

New Member

Date Joined Dec 2009
Total Posts : 1
   Posted 12/8/2009 10:20 AM (GMT -7)   
I have been on remicade for aproximately 6 months now. I weighed in at 210 before and am at 256 now. I cannot attribute my weight gain to anything else. My appetite and diet are the same as always, and my Crohns symptoms aren't any different either. I have had Crohn's now for 4 years, have been on Humira and failed that drug, and now have failed Remicade, next stop is Cimzia (sp)....

Age 28

Current Meds

B12 injections

Surgical History

Bowel Recections - 3 2006,2007
Ileostomy - 2006
Partial Colon Removal 2006
Abdominal Wall Reconstruct 2008
Ileostomy Reversal 2008

Good Days
Regular Member

Date Joined Oct 2008
Total Posts : 146
   Posted 12/8/2009 10:31 AM (GMT -7)   


Why did you stop the Remicade?  I think the weight gain people are experiencing is because they are getting better on the Remicade and therefore can eat again.  When you don't eat for a long long time and then are able to eat again you will gain a lot of weight.  That is why people who go on diets that restrict eating gain so much when they get off the diet.


Hopefully the new drug will work for you.  Remicade worked for me but after my bowel resection I stopped the Remicade.  My chrons is in remission.

My sister-in-law tried Humera and got infections, she is now on the new drug and doing very well.


Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 12/8/2009 5:02 PM (GMT -7)   
I usually gain about 10 -14lbs after having it. But then in a flare I lose about the same! I probably gain about 6lbs in the first week but I think thats because whenever I've had it I've been dehydrated etc and so I reckon at least half of the total gain is water-weight and regained muscle and then the rest is down to me feeling better and being able to eat more and absorb the nutrients better.

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