I had issues with anxiety at higher doses of prednisone (40mg-60mg). I would have panic attacks and scary mood swings - lots of anger, crying, sometimes elation, generally, completely nutty behavior. This is not something that happened to me prior. I worked it out with support from my friends and family and things eased up as I lowered my prednisone dosages. As for fatigue, I am definately tired most of the time. The Prednisone disrupts my sleep so I'm sure that adds to my general feeling of fatigue but can't completely blame it on the Prednisone.
Dx with Crohn's Colitis July 2007
37 yr old working Mom with two beautiful little girls (2 and 4)
Prednisone (20mg), 50 mg Mercaptopurine (6MP), 4.8g Asacol, Vicadin, Imitrex and Ambien as needed
Other stuff: probiotics and folic acid