I've found that if I inject on the side of my upper thigh there is almost no discomfort whatsoever. Took me a couple of injections to figure this out. I also ice prior to the injection. As to flu like symptoms, I take my shot on Fridays after work so I have the weekend to cooperate. I do get headaches primarily from my imuran though. I take it at night so I sleep through the headache.
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.