How Long till Mesalamine/Endocort EC work?

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Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 10/26/2007 3:18 AM (GMT -7)   
Hey everyone,
Obviously I'm new here, but I'm no stranger to the devastating effects of Crohn's disease. I've had it since high school, but wasn't diagnosed until ten days ago. Living more than 20 years with CD and no medical relief wasn't easy. Now I'm really looking forward to getting this thing in remission.
I have CD throughout my entire colon. My doc says that the terminal illeum is not involved, but I have yet to do a capsule endoscopy to determine whether any of the small intestine is involved.
He put me on two tablets of Lialda (mesalamine) per day, and 3 capsules of Entocort EC per day. It's been 9 days, and I still haven't seen any significant relief. It's hard to explain, but I do *feel* different. I'm still having loose BM's, but the associated cramping is.... different. I also have stomach pain pretty much non-stop. It also seems like my whole GI tract is always in motion/action/making noises. This wasn't the case prior to starting these meds. I reported these conditions to the doc, and they suggested decreasing the dosages of both drugs. Well, being as how I haven't seen any benefit at all yet, I talked them out of it. So I'm still taking the same dosages, and not seeing any relief. How long does mesalamine typically take to start bringing some relief? How about the Entocort?
My ability to return to work (it's a long story, too long to tell here) depends upon my ability to get my CD under control. Needless to say, I need to provide for my family, so I'm very anxious to get this under control and get back to work.

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 10/26/2007 4:05 AM (GMT -7)   
Hi, and Welcome to Healing Well. It could take sometime for the the meds to take effect. It may take a couple more weeks.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007

Regular Member

Date Joined Dec 2006
Total Posts : 136
   Posted 10/26/2007 5:51 AM (GMT -7)   
my understanding is that the entocort may not help the entire colon. The mesalamine should though, and a person can take as much as 4.6 grams of that per day. Ask your doc if your mesalamine dose is appropriate.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 10/26/2007 6:20 AM (GMT -7)   
I know when I have taken Entocort in the past it has taken a good 2-3 weeks to kick in. I think its about the same for the Lialda. Sure hope you get feeling better soon.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.

Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 10/26/2007 8:27 AM (GMT -7)   
Thanks for the information, everyone. :)

After waiting for so many years, it's hard to wait anymore.

Veteran Member

Date Joined Dec 2006
Total Posts : 559
   Posted 10/26/2007 1:14 PM (GMT -7)   
Meanwhile, there are some supplements you could try taking. These are non-prescription, fairly low-cost, and unlikely to do you any harm.

The ones I take that seem to be useful:

a probiotic, MSM, vitamin A (fish oil, not betacarotene). Don't overdose on the vitamin A - just one per day. A probiotic once per day is probably enough. You can take MSM up to 3 times daily.

Hope this helps.
Crohn's since 1988
3 resections

Miss UK
Regular Member

Date Joined Oct 2007
Total Posts : 128
   Posted 10/26/2007 3:12 PM (GMT -7)   
I don't know the answers as I have been avoiding those drugs up till now on a recent flair its a hard desease to diagnose and it must be a relief to have a name to your problems all be it a bad one but I wish you all the best of luck for the drugs to work for you so you can start living a pain free life

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 10/29/2007 11:10 AM (GMT -7)   

Do you know where your Crohn's is located? If you have Crohn's only in the terminal ileum, then the Entocort can do the job by itself. And it does take a few weeks to reach full strength.

But if your Crohn's extends well into the colon, then the Lialda can help, as well. Lialda is a new medicine, FDA approved only this past January. 

You could try replacing the Lialda with Asacol, which is similar to Lialda (targets mainly terminal ileum and colon) or Pentasa (similar, but targets entire small intestine and then colon, but less of it gets into colon than Asacol and Lialda). These are all mesalamine meds...basically the same, but targeting different areas. And formulated differently, so some people can tolerate Asacol better than Pentasa or vice versa.

Daughter (20) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress and needing more fiber but landed in hospital in 3/06 with cramps, vomiting, stricture. Now in remission with Entocort 3 mg (one pill), SCD multivitamin, yogurt, vit D3 1800IU, 900+ mg calcium, 50 mg B complex vit, 25 mg iron. No longer on SCD diet.   

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