A combination of drugs that WORK!

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Regular Member

Date Joined Jan 2006
Total Posts : 303
   Posted 10/28/2007 5:58 PM (GMT -7)   
So I asked the doc about pentasa and entocort and he agreed.
My question is of the two which one generally gets weaned first? I think the entocort is exacerbating my anxiety problems. Im very irritable and not fun to be around.
I know entocort is not suposed to be systemic but in my case I think it is. I have had a decrease in acne and a decrease in back pain.
Im on 9mg day entocort and 3000mg day pentasa

Veteran Member

Date Joined Oct 2004
Total Posts : 3932
   Posted 10/28/2007 6:15 PM (GMT -7)   
Entocort is a steroid. If that combo works, that is the drug you will be weaned off of first. As for the Pentassa, its up to your docs beliefs. He may believe its nessecary (sp?) maintance & keep you on it indefinitely. Or he may not..


Regular Member

Date Joined Oct 2007
Total Posts : 208
   Posted 10/28/2007 11:11 PM (GMT -7)   
Well, i'm on both meds. I'm temp. off Entocort b/c I'm on prednisone. As soon as my inflammation calms down I will go back to the Entocort, 3x a day, and eventually once a day. But he said that both pentasa and entocort I'm going to be kept on indefinitely as maintenance drugs. I'm current on 4000 mg of Pentasa daily.
26 year old female  diagnosed with severe Crohn's in Sept. 2007-suspected that I've had it for at least 3 yrs.  Currently taking Pentasa 500mg/8x daily; Entocort 3mg/3x daily; Percocet for pain; Protonix 40mg---was on Flagyl/Cipro for two weeks,(a few weeks ago), was supposed to be on it for three weeks but the cramping and diarrhea it caused made me stop

Veteran Member

Date Joined Mar 2007
Total Posts : 1642
   Posted 10/29/2007 8:25 AM (GMT -7)   

My doc is keeping me on entocort and pentasa as maintenance drugs. I have asked to try to go off entocort but i get sick.

Good luck!



Karen (Karendee)

Diagnosed w/ Crohn’s Disease  March 2007 On Azathioprine (generic Imuran), Pentasa, & ENTOCORT

Diagnosed w/  Fibromyalgia May 2007 also on Soma

Also have Arthritis, and feel like I am falling apart sometimes...

Regular Member

Date Joined Oct 2006
Total Posts : 121
   Posted 10/29/2007 9:34 AM (GMT -7)   

I was on 9 mg of Entocort and 4 gm of Pentasa each day.  As time went on, after the Entocort began, I developed major anxiety issues and hand tremors.  When I was doing okay bowel-wise, we dropped one Entocort out and within 2 days, I could tell there was a reduction in tremors.  Previously, the GI insisted that the tremors could not be from the Entocort so I had to go to a neurologist to rule out MS since other symptoms I had (not related to the Entocort) looked like MS with the tremors.  Oh, well, at least I don't have MS, but the money, the time, the stress could have been avoided had the doctor considered that what I was telling him (tremors began with the Entocort) was possibly reality.

Am trying to get off the Entocort entirely and expect to be kept on the Pentasa, though I am switching from Humira to Remicade so that the dosing can be dialed up to control all-over inflammation likely from the CD that is affecting muscles as well as joints not already affected by the AS.  Hope it pans out as planned since the rheumatologist thinks the Remicade should be able to get me off all other CD meds-assuming I can tolerate Remicade. We'll see....

Wish you well!  Opossumgirl

DX W/AS 1996

DX of CD 8/2006

Taking: Pentasa (1 Gram 4 x Day), Humira (1 Shot Every Other Week), Entocort EC (6 mg), Ultram and hydrocodone as needed for Pain, Advair for Asthma, Synthroid for Hypothyroidism, Metoclopramide as Needed for GP and Nausea, Forvia (2 X Day), Calcium (1200 mg) W/ D Each Day, Milk Thistle (1000 mg daily for liver support), Ambien as needed,

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 10/29/2007 10:04 AM (GMT -7)   
Entocort can work just fine by itself...I doubt the Pentasa helped it work. However, Pentasa can be used to help you wean off Entocort.
Traditionally, doctors wean patients off steroids and onto "safer" meds like Pentasa, because these meds are thought to have fewer serious side effects than steroids, even steroids like Entocort, that target mainly the terminal ileum, and therefore are not as likely to cause serious side effects.
3 grams of Pentasa is a little low. If you really want to avoid a flare, then it would be safer to try the full dose of Pentasa, 4 grams, when you taper completely off Entocort.
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