Biospies are Normal?

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Regular Member

Date Joined Aug 2005
Total Posts : 289
   Posted 11/2/2007 1:38 PM (GMT -7)   
Believe me I am thrilled they are normal but I am not and that is the problem.  They gave me pamine forte which only caused more symptoms then I presented with.  Sure it could be IBS but why do I have a draining infection in my anus for 3 years and why did I respond beautifully to prednisone.  Where do I go next or since it doesn't affect my work and function too much should I just let it go for now and consider it some sort of intermittent inflammatory thing related to the RA? 
dx: Rheumatoid Arthritis.  Duration: 10yrs. Dx'ed 2006.  Asthma, hypertension, hypothyroid
Meds: Methotrexate 25mg wkly, Arava 20mg, Rituxan infusion, Folic Acid, Fish Oils, Advil, Advair 250/50, Diovan HCT 160mg/25mg QD, Women's One a Day, tylenol PRN.

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 11/2/2007 5:12 PM (GMT -7)   
Hi I am not sure what you should do but what did the Dr. say was causing your drainage? I am glad that your test was good. lol gail

Regular Member

Date Joined Sep 2007
Total Posts : 32
   Posted 11/2/2007 10:29 PM (GMT -7)   
My GI said all my clinical symptoms add up to Crohn's disease- but each of my biopsies came back normal. She is treating me as a CD patient anyway, since I am responding (more or less, less right now) to the medications. I think I have read of others in the forum who have had biopsies which confirmed CD one time, then clean biopsies on a later test.

There is nothing wrong with asking more questions or requesting more tests.


Regular Member

Date Joined Jun 2005
Total Posts : 369
   Posted 11/3/2007 7:56 AM (GMT -7)   
Every biopsy I ever had came back normal right up to the time they removed 10 inches of my small intestine. My GI even said he was able to "get through" to my terminal ileum, which I now know was impossible because it had completely closed off by that time. Don't give up..........sometimes we're our only advocate. Good luck.

Veteran Member

Date Joined Jan 2004
Total Posts : 598
   Posted 11/3/2007 8:04 AM (GMT -7)   
Vic, sounds like your situation is similar to mine. My doctor is also treating me based on the response to medication I've had. It is my understanding, since CD can be spotty, it is sometimes hit or miss with the biopsies. Unless there was obvious pathology, he may have hit the wrong spot. OR, you might have CD in an inaccessible spot, like above the terminal ileum. That would produce the symptoms without the evidence.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now trying good ol' zoloft

Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 12/27/2007 12:11 AM (GMT -7)   

I am glad I found this post!  I am currently going through the same kind of thing...the GI doctor found 3 or 4 areas of inflammation throughout my tract but the biopsies all came back as normal and self-limited.  I guess it does go to show that sometimes it takes time to find out, unfortunately! 

It is confusing, too, when the GI doctor thinks you are ok but your internist does not...I really need to ask my internist what's next??

Regular Member

Date Joined Nov 2007
Total Posts : 111
   Posted 12/27/2007 11:18 AM (GMT -7)   
i went threw same thing!! I have had 2 colonoscopies before didnt show anything but mild inflammation was on steriods and stuff now they made me for this last colonsocpy get off steriods and they found it in 7 spots threw out small and large intestine. They said get off medication and flare as bad as you can and sure enough they found he biopsied the bad areas and they found it. Still in the early stages of it not as bad as some people so we are trying to get it under control with steriods, humira, and pentasa. Hope it works.
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