Contemplating 6-MP..

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New Member

Date Joined Nov 2007
Total Posts : 1
   Posted 11/15/2007 11:50 PM (GMT -7)   
 Hello, my name is Eva i am new to this forum ; im 20 years old and was diagnosed with crohns 2years ago; ive been hospitalzed 4 times so far.. with a few weeks spent on IV solumedrol and many many months spent on prednisone (started at 80mg) currently on 15mg.. and endocort, and asacol. Nothing really helps expect for prednisone!
since the beginning my GI suggested i go on 6-MP among others, such as Imuran and Remicade. for two years i have been trying alternative natural therapies and vitamin supplememnation and probiotics. My longest remission off of prednisone was when i had a vegetarian diet- but i had alot of hair loss during this time. When i got a colonoscopy after 6 months of no symptoms my GI said i was in clinical remission; lo and behold 2weeks after the colonoscopy i was in the hospital with my second acute flare.
In the past 5months ive been unable to taper down prednisone or endocort, so i decided to take a step and consider 6-MP. I feel like i have many more natural alternatives i want to try but i cant get in the clear and away from acute flare ups- especially since im in 3rd year university and cant afford to miss anymore exams!
Last week my GI did the test to see if i can take 6MP and it just came back clear. I would start 50mg for 2 weeks and then this a normal dose? Any help would be so great! i have so many questions and i am reluctant to start it but ive also heard such positive stories from people who have been on it. im not sure what to expect, should i restrict any normal things i do? Im wondering if i should try other approaches or give this a try...

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 11/16/2007 4:53 AM (GMT -7)   
Hi Vavi, Welcome to Healing Well, It is normal to start on a low dose of 6MP and then go up to a higher
dose. I also am doing Imuran which is a 6 MP drug. Your doctor will be doing blood test on ocassion its normal
I haave then done also. I hope the 6MP works for you.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007

Regular Member

Date Joined Apr 2007
Total Posts : 254
   Posted 11/16/2007 5:00 AM (GMT -7)   

Hi Eva and welcome!!!

I am not on 6-mp myself, but I'm trying to convince myself to take it, I know it's the next step for me, because I cannot be on steroids forever.  Here in Greece CD is very rare, but I met someone last year who is a CD patient and is on 6-mp for almost 6 years.  He told me that since starting 6-mp he feels completely healthy, he enjoys his life and sometimes he finds it hard to believe he actually has CD!!  Before that, he was struggling for two years with CD, going to the bathroom almost 30 times a day, having joint pain and fever everyday.  Now considering he is a manager in a big company, he couldn't cope with this anymore, so he decided to try the 6-mp.  His life changed, he travels around the world with his wife, and his moto is "I'd rather live 10 years enjoying everything life has to offer, than live 20 years feeling miserable".

On the other hand I am only 34 years old, and I plan on living much more than just 10 years, but I also want to live a quality life, and not a miserable one. 

As you see it is a very personal decision, each one should really consider the pros ans cons.  And of course you have to keep in mind that not everybody gets side-effects from the medicines.

Onoy you and your doctor can really decide what's best.  I wish you good luck to whatever decision you make...

Christina tongue


Regular Member

Date Joined Sep 2007
Total Posts : 330
   Posted 11/16/2007 5:26 AM (GMT -7)   
Hi Eve -- I wanted to say welcome to HealingWell. I'm new to the forum and have gotten lots of good advice/support here.

I was just diagnosed a few months ago, but have already started 6 mp (50 mg) because I can't taper from the steroids and those side effects are very undesirable to me. As someone already said, it's about quality of life. I'm a single mom and work full time. I am trying to find a solution that keeps me feeling as well and functional as possible, and I'm hoping 6 mp lets me do that with fewer (or no) steroids. You have decide what the trade-off is for you. Many people on this forum are on 6 mp with few or no side effects. (If you look back a few pages on the forum you'll see several current 6 mp threads that may give you more side effect info.)

Good luck to you whatever you decide!
Official dx September 2007.
Medications: 6 mp, Pentasa, Prednisone (tapering), Prilosec, Synthroid.
Supplements: probiotics, calcium, vitamin C, vitamin E and a multi-vitamin.
History of hypothyroid (dx 2004), and gall bladder surgery (1997).
44 years old; single mom to three wonderful kids, ages 9 to 15.

Veteran Member

Date Joined Sep 2007
Total Posts : 565
   Posted 11/16/2007 6:50 AM (GMT -7)   
welcome vavi, just wanted to let you know that i just went on 6mp yesterday and completely understand the anxiety of starting it. i got really depressed when i picked up my new script the other night, kinda like a "what have i become?" kinda feeling. i don't want to live off all these drugs. but i also can't live like this anymore. i should not have to take vicodin just about every day to function. and now that i have been tapering down on the prednisone the d is coming back :/ my spirits are not too high i admit. BUT, i did take my first pill last night, guess the rest will be easy. i go for my first blood work on wednesday next week to see how i am tolerating it. this is my last option before surgery. i guess i will just have to wait and see what the next few months bring. blah blah blah i am rambling!

good luck to you in what you decide to do. i have read a lot of success stories from 6mp, more so than bad stories. take care!
.: stephanie :.
32 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
15mgs prednisone (getting there!), 25mgs 6mp, 4000mg pentasa, vicodin for pain & boat load of other drugs for sleep and anxiety!

Regular Member

Date Joined Oct 2007
Total Posts : 208
   Posted 11/16/2007 8:21 AM (GMT -7)   
Welcome! I myself "bit the bullet", so to speak, and was just started on Imuran 50mg/3x a day. I'm also tapering off prednisone, which has done NOTHING for my symptoms, although has made me gain 10 lbs and make my face puffy! I haven't noticed any side-effects from the Imuran yet. Good luck!
26 year old female; diagnosed with severe Crohn's in Sept. 2007-suspected that I've had it for at least 3 yrs; diagnosed with anemia Aug. 2007.
Pentasa 500mg/8x daily; Entocort 3mg/3x daily; Percocet/Ultram for pain; Protonix 40mg---was on Flagyl/Cipro for two weeks,(a few weeks ago), was supposed to be on it for three weeks but the cramping and diarrhea it caused made me stop
Prednisone 20mg and tapering, back on the Entocort...
Neurontin 6 capsules/day
Ferrous Sulfate 325mg/daily for anemia
Bentyl, 3x/day
Azathioprine 3x/day

Mormor Vicky
Veteran Member

Date Joined Mar 2007
Total Posts : 684
   Posted 11/16/2007 2:41 PM (GMT -7)   
Welcome Vavi, Good luck on 6mp if you decide to go that route. Your dosage sounds about right. My doctor started me at 50mg, upped to 100mg, and raised it again to 150mg. I think that was too much. Make sure you keep your doctor appraised of any side effects you might have. My doctor had told me when I complained about side effect of the pred that all meds have side effects, that I would just have to learn to live with them. When I went to him when I developed ulcers on my mouth thinking it might be crohns of the mouth. He told me that it was the herpes virus. To go to my PCP for treatment. She treated them but they just got worse and worse. After three weeks I ended up in the ER because I couldn't eat or drink anything. My mouth looked like raw hamburger meat. Nothing worked to fix. Turns out I had bone marrow suppression caused by the 6-mp. Ended up in isolation at the hospital for eleven days. To say the least the GI is no longer my doctor. I know many people who have wonderful results and I had a very rare reaction but please stay intuned with your body. You know it best.
Vicky / 47 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
Daughter (26) also has Crohn's since she was 12.
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 11/16/2007 11:53 PM (GMT -7)   
Eva, my daughter is your age and I'm amazed at how young people do so much in spite of having to deal with Crohn's. 
If you are thinking of starting Imuran, the TPMT blood test can help identify whether your body makes enough of an enzyme to deal with this particular medicine -- if it doesn't, could cause dangerous bone marrow suppression. Evidently about 1 in 300 people doesn't have the enzyme.
Daughter (20) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress and needing more fiber but landed in hospital in 3/06 with cramps, vomiting, stricture. Now in remission with Entocort 3 mg (one pill), SCD multivitamin, yogurt, vit D3 1800IU, 900+ mg calcium, 50 mg B complex vit, 25 mg iron. No longer on SCD diet.   

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