The diagnosis is tentative until you stop the medication, then when the symptoms stop, you know for sure (although the longer you're on the drug, the longer it takes for the symptoms to dissipate, it took 4 months after I stopped the Remicade).
I've never had any arthritis pain before in my life (except for maybe a twinge or two), and I've had this disease for most of my life. I also had the Remicade antibody test and my antibodies were extremely high. There's also a whole time line you go by. Second exposure to the drug along with delayed reaction, the nature of the pain meaning
location, being migratory, etc. I was told by the specialist that my symptoms were classic signs of serum sickness and to get off the drug. It worked, the pain went away.
I'm still doing research, and may have to go see my specialist again, but I have the feeling this all started with Remicade. I was leery of going on the 6mp because my liver enzymes have been all over the place, but the funny thing is that right now they're normal, go figure.
I ordered a book I found that was co-authored by my specialist (Inflammatory Bowel Disease from Bench to Bedside, Second Edition, a little light reading while I'm sitting with my father-in-law during Chemo tomorrow, lol), hopefully it will have some answers in it, if not, I'll have to bite the bullet and make another appointment with him (after I mortgage my house to pay for it, lol).
I'm going to go to an allergist also, but the tests won't necessarily show a reaction, the only way to see it will be to take the drug in a controlled manner and I'm not sure I want to do that. I have seen research showing that it's possible to desensitize to 6mp, but not sure what that entails and I may be better off just trying the Methotrexate.
This is so frustrating. The only other thing I've ever been allergic to is IV Iodine, and that was a reaction I had 30 years ago, nothing since.
I long for the good old days when GI's didn't want to see me in between surgeries, when remission was a break from the doctors. Now we know better, we know I should be proactive, try to prevent another flare, but my body won't cooperate.