I've been told the same as belleenstein by a couple of gastros - that Asacol has a very short life span, so you need to take it 3 times a day to keep the gut under control. I've never had to eat food with it.
I used to play around with not taking it, or taking less, because I felt just fine, but eventually, I didn't feel fine anymore. For me, I've learned that it's easier to just get into a routine of taking it on the same schedule, every day.
I used to take 3 Asacol, 3 times a day, but now I take 2 Colazal, 3 times a day.
DX: mild to moderate Crohn's for 34 years
Additional benefits: chronic anemia, B12 deficient, peripheral neuropathy, facial mylagsia, joint pain, underactive thyriod
Current meds: Colozal, Nexium, Entocort, Flagyl, steriod cream, monthly B12 injections, Neurontin, Synthroid, Effexor ER, pain meds as needed