I've been on Entorcort 3 times over the past seven years and have never noticed any side affects. I think prednisone worked much better for me in terms of stopping a flare quickly, but the side affects are awful. I'd rather take Entorcort for 3-6 months and get over the flare slower than deal with the prednisone side affects.
As Crohns drugs go, I consider Entorcort to be one step above the 5-ASA drugs, which are also well tolerated and have few, if any, long term side affects. It's way safer than the 'harder' drugs, like Remicade, Humira, Imuran, 6-mp, etc....
Everyone is different, so none of us really knows how a new drug will affect us until we try it. I hope it works for you.
DX: mild to moderate Crohn's for 34 years
Additional benefits: chronic anemia, B12 deficient, peripheral neuropathy, facial mylagsia, joint pain, underactive thyriod
Current meds: Colozal, Nexium, Entocort, Flagyl, steriod cream, monthly B12 injections, Neurontin, Synthroid, Effexor ER, pain meds as needed