Sorry, you can't take it in the butt. I just did my 3rd treatment today. I was told by the nurse, only the stomach and/or upper thigh -- right or left leg.
I ice it down for about 15 to 20 min to get the area nice and numb. it helps alot.
Take the Humira out of the fridge and let it sit while you ice up.
You can also take a Benadryl about 30 min before the shot.