Actually, I have had the opposite effect from the other posters. However, I am not on Remicade or Humira. Since being on the Imuran, my allergies to the cats is much worse. Whenever I go to my ex in-laws' house within half an hour my esophagus is burning, my throat and ears are itching and I lose my voice. Even if the pets are in another room. Maybe the Remi/Imuran or Humira/Imuran combo produces different results??? Or maybe I am just a freak of nature. LOL. Either way, my pet allergy is only compounded by the Imuran.