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Regular Member

Date Joined Sep 2007
Total Posts : 123
   Posted 12/17/2007 3:53 PM (GMT -7)   
How many of you are on methotrexate or have been on it before. If you are on it how long has it been? Is this a drug where you can be on it for long periods of times? (i.e 10+ years if necessary?) Also what side affects have you experienced? Thanks.
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Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 12/17/2007 4:52 PM (GMT -7)   
I have been on methotrexate for a little over 5 years. After official diagnosis and he fact that steroids were doing nothing for me and I was alergic to Pentasa they decided to try this. I take the oral tables 25mg a week which is considered high dosage which the docs aren't too happy about as it is quite a toxic drug but as its keeping me well at that level they're OK with me staying on it until I've finished uni etc and got my life together before trying to get me onto something else. I think its the female factor as well as having kids on this drug is a massive no no.
I started out on it on its own with folic acid once a week to reduce side effects and limit any damage, I have bloodtests once a month to make sure my livers not being damaged etc by it. It worked well on its own at first, within about 2 months my symptoms were greatly lessened and my inflammation levels had dropped but still wasn't total remission. It was a few months later when I was facing surgery they tried me on an infliximab infusion as well and thats what kicked me into remission and the methotrexate also works as a maintenance drug with infliximab and that has kept me very healthy the last few years.
The only side effects I have experienced were when I first started after the first couple of doses I'd have mini hallucinations for a couple of hours and see colours and shadows behind me - quite bizarre, but that stopped after a few weeks of taking it. To begin with my hair thinned a bit but that also stopped and other than that I have bad nausea with it so I take it at night to sleep through most of it and then the next morning I take prochlorperazine (quite a strong anti-sickness med, it took trying quite a few different ones until I found one that worked) to stop that.
So yes you can be on it for long periods of time but as long as you're closely monitored and its suitable for your situattion

Veteran Member

Date Joined Mar 2005
Total Posts : 4305
   Posted 12/17/2007 5:03 PM (GMT -7)   
Hi,if you don't mind are you talking about the pill or the shot?when I was on it I showed how to give my self a shot I took once a week and I had no side effects from it; but how ever my dad rook the pill form and he would get sick but once he was changed over to the shot he was fine.There are others that are on and I am sure they will be along soon.

Regular Member

Date Joined Dec 2006
Total Posts : 371
   Posted 12/17/2007 9:37 PM (GMT -7)   
shot,,,over 5 years now, once a week
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Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 12/17/2007 10:40 PM (GMT -7)   
I was on MTX for about 3 months -- once a week shots. After no signs of improvement after 3 months, my doc discontinued. but one of the infusion nurses had been on it for years for RA.

Regular Member

Date Joined Sep 2007
Total Posts : 160
   Posted 12/18/2007 4:32 AM (GMT -7)   
Ive been on metho almost a year now and it appears to be working considerably well seeing as i have not been in hospital at all this year for the 1st time since being diagnosed in 2004 the only disadvantage with the metho is it lowers your immune system and your prone to catching all kinds of infections apart from that im fine no side effects at all.
I take 5mg of folic acid every monday and have monthly bloods.Im on it long term sorry forgot to mention weekly injections i tried the oral metho but it never agreed with me .
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