Had Anyone Ever Had Prednisone Cause .... ???

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Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 12/19/2007 5:37 PM (GMT -7)   
I realize this question may sound ... dumb .. from someone who has had CD for 32 years but ....
Has anyone ever had prednisone CAUSE aching hips and joints?
Just prior to my resection back in 1978 I spent 6 weeks in hospital on IVs and an NG tube and I ASSUME most likely was given IV pred. Other than that I've only had one shot IV doses in ER and one 6 week w/taper of Entocort. Ooops - and one 6 dose pack of methyrlprednisolone for shingples.
Yesterday I finally had to cave in and agree to do a short regimen of oral prednisone. Just 40 mg for 3 days, then 30 mg for 3 days, etc. down to just 10 mg for the 10th thru 12th day.
I took my first 40 mg dose this morning. It was like a miracle drug for the COPD!!! BUT - this evening my hips have started ACHING. BAD. I've never had trouble w/my hips aching. Nor joints. Muscles, yes, bones, yes, on occasion, but not like this and not the hips. Maybe it was just the 2 hour drive to U of M yesterday and the 3 hour drive home (rush-hour traffic!) but if so WHY didn't it hit until THIS EVENING?? On the other hand it IS only ONE 40 mg dose I've taken. But nothing else is difference and this sure isn't the first time I've made the drive to U of M and back in one day!! I had on loose clothing both yesterday and today. Nothing binding in the hip area or elsewhere.
Just curious. And aching. And hitting the Tylenol Rapid Release capsules BIG TIME!
Whine, whine, sniffle. yeah Getting to be a PANSY in my old age.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Forum Moderator

Date Joined Apr 2007
Total Posts : 32602
   Posted 12/19/2007 5:49 PM (GMT -7)   
Hey there kiddo, sorry your having the joint pain. Actually Steroid medications are often used to treat joint pain so I am stumped.
My husband has been on the Prednisone many times and not c/o pain to the hips or joints.
This does not mean it cannot happen. Hope the Tylenol helps you as I hate to hear your in pain.
Gentle Hugs to you
Moderator Anxiety ~ Panic Disorders
*~* Not a mental health professional at all *~*
Dx: Anxiety/Panic, Depression, GERD, Osteoarthritis
*Wife of a Crohnie*
It is health that is real wealth and not pieces of gold and silver.~Mahatma Gandhi~

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 12/19/2007 6:19 PM (GMT -7)   
You must be in pretty bad shape to agree to take the dreaded pred.?! :) I had horrible joint pain on pred. I was on 60 mg. at the time, and it was after I had been on it a month. I happened to be in the hospital at the time and my knee hurt so bad that 100 mg of demerol didn't even touch the pain, and I was literally crying for hours it was so bad. I also had other incidents but not as bad....and it always seemed to be my knee or elbow, but darvocet would take the edge off of it.

Veteran Member

Date Joined Oct 2006
Total Posts : 2079
   Posted 12/19/2007 7:11 PM (GMT -7)   
Hi CT,

Prednisone can do all sorts of things, joint pain included. My daughter just did a short stint and was bothered in this way. She had been on methypred earlier this year (asthma and bronchitis) and it didn't cause the side effects like she had on prednisone. I usually only get joint pain when I'm going off it, not on it though. -Joy
48 yr. old. Ileocolitis.  CD since early teens, misdx'd until age 36.  Hemicolectomy-left side in 2001.  Disease returned in 2003. Arthritis, episcleritis, chronic pain due to surgeries (nerve damage, adhesions) and disease.  Recently dx'd scoliosis.  History of endometriosis.

Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 12/19/2007 7:12 PM (GMT -7)   
Thank you, Kitt and CMom2x, this is just the first dose. Its kind of hard to believe as I was pretty sure they do use pred for joint pain. But its the only thing different .... yeah, CMom2x, have been extremely SOB outta the blue since Saturday night (the 15th) so had come to the conclusion on my own that if they suggested pred I'd give it a go - and, of course, that was the first suggestion out of their mouth. Desperate circumstances sometimes call for desperate measures and I finally got desperate enough .... we'll see what tomorrow brings. If I'm lucky it was just the 5 hours driving .... I'm hoping anyway. Popping a second Tylenol Rapid Relief now. I'm hoping my luck hasn't run out w/the Tylenol as I've yet to take an oral pain med that didn't make me nauseous and pukey.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Regular Member

Date Joined Jun 2003
Total Posts : 280
   Posted 12/19/2007 11:20 PM (GMT -7)   
C2, I haven't had the joint pain,(well I do all the time from the arthritis, but not the pred), but I did have excruciating cramping in my ankles after only 3 five mg. doses of pred. The GI prescribed a short course after I tweaked my wrist and it was very swollen on top of the constant pain. So I tried the pred, but the cramping was so bad it woke me up several times and I wore the carpet out, trying to walk out the cramps. Finally got in a really hot bath and the cramps subsided, but I didn't take anymore, even though I know you're supposed to taper off. I've had leg and foot cramps at night before, but never as bad as these ankle ones were. Have an appt. with the GI next month, hope he's not pissed that I quit. Sure sounds like you're reacting to the pred, hope you can get past it. Hope you're feeling better. Bets

Regular Member

Date Joined Apr 2006
Total Posts : 449
   Posted 12/20/2007 1:03 AM (GMT -7)   

Sorry you're having so much pain. I hope it stops quickly. But, you may want to check out this information on Avascular Necrosis to see if it fits your symptoms.

This is from the John Hopkins Vasculitis Center information on side effects of prednisone.


Avascular Necrosis of Bone
For reasons that are not known, high dose prednisone (for example, greater than 20 milligrams a day) predisposes some patients to joint damage, most often of the hips. In avascular necrosis (or osteonecrosis, meaning “bone death”) of the hip, the part of the leg bone that inserts into the pelvis dies, resulting in pain with weight–bearing and some loss of joint function. Many patients with avascular necrosis require joint replacements.

And from the Penn State Medical Center Health Library there's a lengthy description of the causes, symptoms and treatment at this website


Avascular Necrosis

Studies now show that there is an increased incidence of AVN seen in people who chronically use steroids (such as prednisone) which are commonly used to treat diseases in which there is inflammation, such as systemic lupus erythematosus, rheumatoid arthritis, and vasculitis. Long-term, systemic (oral or intravenous) steroid use is associated with 35% of all cases of non-traumatic avascular necrosis. However, there is no known risk of AVN associated with the limited use of steroids. Doctors are not exactly sure why the use of steroids sometimes leads to AVN; they may interfere with the body’s ability to break down fatty substances which in turn build up and clog the blood vessels, causing them to narrow, which reduces the amount of blood that gets to the bone.

All the best

Veteran Member

Date Joined Mar 2005
Total Posts : 4305
   Posted 12/20/2007 1:46 AM (GMT -7)   
OH boy do I feel for you!!!!!We all react to meds differently and prednisone is no different.When I was on steroids I kept telling my GI that the prednisone is what was causeing my lungs to act up and they looked at me like I was crazy let me tell.Well it got to were I could no longer breathed got put in the hospital and by this time I was so bad off that I no longer could breath by my self was put on a breathing machine I was in there for eight long day's on that machine.I was not doing musch better and this whole time I was still getting the prednisone and finally my ex-husband insisted that another doctor be brought in and well it did not take that doctor the whole sum of forty five minutes to tell my other doctors that I was allergice to prednisone and that was the sorce of the lung problems I was having so he got to gether with my GI and both take me off of the prednisone and with in two day's I no longer needed that machine.I was having sever joint pain as well.Now I do have RA,OA but the prednisone made it worse.I am not trying to scare you by any means but for some yes it helps improve there condition rather it's for there joints or the gut or there lungs but some like me it has an adverse effect.I hope that you get to feeling better and if you are not feeling any better by tomorrow please call your doctor and tell him/her what is goin on.Please let us know how you are doing.

Veteran Member

Date Joined Jan 2003
Total Posts : 6117
   Posted 12/20/2007 3:24 AM (GMT -7)   
hey C2, i used to have terrible hip and knee pain when i was on long term use. but never had it happen so fast with such a small dose. good luck with it though


Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 12/20/2007 8:11 AM (GMT -7)   
Well C2 you are not alone. When I take Prednisone it seems as if I am always aching really bad. I got really bad cramps last time I was on it. I also felt like my calf's got really swollen. When I would wear slacks with knee high stockings, I had to continually adjust them because they felt like they were cutting my circulation off. I think if I ever need steroids again I will ask for Entocort, I have alot less side effects with that. Feel better!
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.

Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 12/21/2007 4:05 AM (GMT -7)   
Thanks everyone. I'm still not clear on the cause or what is going on. I took the second does of 40 mg pred Thursday as when I woke up I had no hip pain or aches. I was fine all day up until about 6PM when the hips started in aching again. Being a bit smarter this time I immediately took a Tylenol Rapid Release. Which did help. But I did have SOME very minor swelling of the ankles. AND the knees down to ankles started in too. So I gave the first Tylenol an hour head start and then popped the second one. At least this kept everything to a low roar, bearable level. No where near so bad as the first night on pred. There is STILL the possibility that it was the 5 hours of driving as things were not so bad last night as the previous night altho it had spread from hips to hips plus knees to ankles. So we shall see what today brings. Meanwhile I will be sure to discuss this w/the sleep pulmo at my appointment today.

The pred has worked like a miracle for the lungs. Within just a matter of an hour or few hours the improvement was drastic!!! It creeps up on you so gradual that you don't realize how quickly short of breath you become UNTIL you get such drastic relief as the pred brought. I went shopping w/o 02 both Wednesday and Thursday yet Tuesday I wasn't able to walk from the valet service at U of M's entrance to the information desk w/o getting so SOB I had to use 02 the rest of my day there. Now THAT is DRASTIC RELIEF!
RLSNights, thanks for the info on pred and AVN. I'll definitely keep that info in mind!!! Thanks too for the links. Leave it to me to come up w/this right at the holidays when docs aren't going to be available in the office. I HATE bothering them outside of office hours ... but I'm not a masochist either. I'm not sure about the MedExpress hours but we do have some of them around here too. And if I get to the dead and dying stage there is always ER. *weak smile*
At least it waits until evening to hit. I made an EZ Apple Pie yesterday to take to the staff at the sleep lab today. Didn't get a chance to get some made for my family doctor and gastro's office. Ah well. I'm sure they will survive.

Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Post Edited (CrohnieToo) : 12/21/2007 4:14:49 AM (GMT-7)

Veteran Member

Date Joined May 2005
Total Posts : 4219
   Posted 12/21/2007 5:32 AM (GMT -7)   
I haven't had a chance to read the responses but I just wanted to let you know that I had joint pain while on entocort and especially while weaning off of it.
26 Year old married female.  Diagnosed w/ CD 3 years ago, IBS for over 10 years before that, which was probably the CD.  Currently on Pentasa 4 pills/4x day, hysociamine prn, nexium, and ortho evra.  Good times!!!

Jack S.
Regular Member

Date Joined Feb 2004
Total Posts : 351
   Posted 12/21/2007 8:44 PM (GMT -7)   


    Haven't talked to you in so long I hate I cought you poorly.

Can't stay long or I'll be doing the old whoe is me tune. Not

justafiably (I wish I could spell that word) Maybe you can

decode it.

   I believe pred can and will do most anything to you. It has

always been good to me out side of gaining a ton on it but

so many have suffered on it, Best I remember gaining wont

hurt you at all. Hope you get to feeling better.

   GOD Bless




Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 12/22/2007 4:20 AM (GMT -7)   
Fitzy and Jack, thank you. Yeah, I have to say that the pred has improved my appetite. Not eating us out of home by any means but since I haven't been eating for beans again .....

Well, this new sleep pulmo doc wasn't happy w/my 02 sats and HR so he really was intent on addressing that issue and, of course, I had my own agenda. Since he wasn't yet familiar w/my file and my sleep data he got caught up in the COPD and like I say I had my own agenda .... my hips weren't bothering me a bit, appointment was too early for that evidently .... to make a long story short, I walked out w/a script for a blood draw and Requip for RLS/PLMs and never even thought about the pred and the hips .... I had given the staff my data downloads including my list of questions and it got misplaced and wasn't in his file w/the data printouts .... no idea where my list of questions went!!!

And, of course, everything was fine until about 6PM. But its very mild, don't even need Tylenol I don't think. Tomorrow I drop to 30 mg of pred so .... I'd guess it was just that 5 hours of driving plus the sitting at U of M. We shall see. I do have some minor swelling of feet and ankles. So I'll watch it.
Ticks me off I lost my list of questions. I had them right there in the clinic before I saw the doctor. They were on a 8 x 11 sheet of paper. Its not like I had them on some post-a-note. I swear I'd lose my head if it weren't attached and I can't believe how I am messing up and wasting my doctor appointments by not covering the issues I intended. Twice now, two different doctors, different issues. I'm slipping. Badly!

Despite all that this doc does seem like a pleasant fellow and interested in his patients. We shall see. Depends on what he comes up w/when he's had a chance to bring himself up to snuff on my sleep studies, etc. I've made no secret I am seriously considering a second opinion somewhere so .....

Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Post Edited (CrohnieToo) : 12/21/2007 9:26:07 PM (GMT-7)

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