trouble with care routine

I have two boys (ages 3 and 18 months) that have both been diagnosed with atypical CF. They have both cultured positive for pseudomonus (sp?) and are sick often. My oldest seems to have the worst of it, and is sick frequently. Right now they both have pneumonia again. My youngest has been on the same care routine as my oldest for several months now. However, since they are both sick, their doctor has upped their routine to two different neb treatments for a total of 6 treatments a day, and their vest 4 times a day. My oldest is a champ and handles all the treatments really well. The youngest on the other hand turns into the incredible Hulk every time we have to sit down and do this. I have tried absolutely everything I can think of to keep him calm while we do his treatments. He thrashes, claws, screams... the whole nine yards. It's literally like alligator wrestling. I figured by now he would have gotten used to it, but that clearly is not the case. We've tried turning on his favorite show, reading, singing, coloring, playing with his favorite toys... the list goes on and on. I've even tried doing his neb treatments while he's sleeping, and that is a complete bust. I am at an absolute loss as to how to get him to calm down so his routine isn't a full on battle 10 times a day. It's exhausting for both of us.